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Science 17 December 1999:
Vol. 286. no. 5448, pp. 2245 - 2247
DOI: 10.1126/science.286.5448.2245
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News of the Week
MICROBIOLOGY:
Promising Antibiotic Candidate Identified
Martin Enserink
Pathogenic microbes are becoming increasingly resistant to antibiotics, including vancomycin, a longtime antibiotic of last resort. Now researchers have come up with a possible vancomycin replacement--one that might lead to a whole new generation of antibiotics. On page 2361, a Dutch-German team shows that a small proteinlike molecule called nisin kills bacteria by latching onto a cell membrane molecule known as Lipid II and opening up holes in the membrane. Because Lipid II is the same target used by vancomycin, the result suggests that nisin, or derivatives of it, could one day replace vancomycin as a broad-range antibiotic.
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THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
- Dissection and Modulation of the Four Distinct Activities of Nisin by Mutagenesis of Rings A and B and by C-Terminal Truncation.
- R. Rink, J. Wierenga, A. Kuipers, L. D. Kluskens, A. J. M. Driessen, O. P. Kuipers, and G. N. Moll (2007)
Appl. Envir. Microbiol.
73, 5809-5816
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- Production of Dehydroamino Acid-Containing Peptides by Lactococcus lactis.
- R. Rink, J. Wierenga, A. Kuipers, L. D. Kluskens, A. J. M. Driessen, O. P. Kuipers, and G. N. Moll (2007)
Appl. Envir. Microbiol.
73, 1792-1796
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| Full Text »
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- NisT, the Transporter of the Lantibiotic Nisin, Can Transport Fully Modified, Dehydrated, and Unmodified Prenisin and Fusions of the Leader Peptide with Non-lantibiotic Peptides.
- A. Kuipers, E. de Boef, R. Rink, S. Fekken, L. D. Kluskens, A. J. M. Driessen, K. Leenhouts, O. P. Kuipers, and G. N. Moll (2004)
J. Biol. Chem.
279, 22176-22182
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