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Science 17 December 1999:
Vol. 286. no. 5448, pp. 2244 - 2245
DOI: 10.1126/science.286.5448.2244
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News of the Week

CLINICAL TRIALS:
Gene Therapy Death Prompts Review of Adenovirus Vector

Eliot Marshall

For the past 3 months, faculty and staff members at the University of Pennsylvania's Institute for Human Gene Therapy have been trying to understand why a relatively fit 18-year-old with an inherited enzyme deficiency died on 17 September, 4 days after doctors at Penn injected a genetically altered virus into his liver. Last week, they presented their data to a government advisory committee. The patient was the first in a gene therapy trial to die of the therapy itself; his death is the latest blow to a field that has been struggling to live up to the promise and hype surrounding the first gene therapy trials a decade ago.

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Development of lentiviral vectors for gene therapy for human diseases.
G. L. Buchschacher Jr and F. Wong-Staal (2000)
Blood 95, 2499-2504
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Local Delivery of Plasmid DNA Into Rat Carotid Artery Using Ultrasound.
Y. Taniyama, K. Tachibana, K. Hiraoka, T. Namba, K. Yamasaki, N. Hashiya, M. Aoki, T. Ogihara, K. Yasufumi, and R. Morishita (2002)
Circulation 105, 1233-1239
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