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Science 19 November 1999:
Vol. 286. no. 5444, p. 1441
DOI: 10.1126/science.286.5444.1441i
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The major cause of death for patients with cystic fibrosis is the massive chronic infections with Pseudomonas aeruginosa that they acquire. Ernst et al. (p. 1561) have found that the bacteria adapt to the particular environment of the patients' lungs by synthesizing lipopolysaccharides with a specific structure. This modification in lipid A is associated with an increased inflammatory response and resistance to antimicrobial agents.




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Science. ISSN 0036-8075 (print), 1095-9203 (online)