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Science 10 September 1999:
Vol. 285. no. 5434, p. 1685
DOI: 10.1126/science.285.5434.1685
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Perspectives

MOLECULAR BIOLOGY:
Ribozymes in the Nucleolus

John J. Rossi

Ribozymes are RNA molecules that behave like enzymes, cleaving other RNA transcripts into pieces. They have potential therapeutic value because they can be designed to chew up viral RNAs or to repair damaged mRNA transcripts. However, getting the ribozyme to the correct part of the cell where the target RNA resides is a challenge. In his Perspective, Rossi explains how small RNAs that inhabit the nucleolus can be engineered to transport and sequester ribozymes into this subcellular organelle. He goes on to discuss the many possible applications of these so-called snorbozymes.

The author is in the Department of Molecular Biology, Beckman Research Institute of the City of Hope, Duarte, CA 91010, USA. E-mail: jrossi{at}coh.org

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THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
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L. K. Gifford, J. B. Opalinska, D. Jordan, V. Pattanayak, P. Greenham, A. Kalota, M. Robbins, K. Vernovsky, L. C. Rodriguez, B. T. Do, et al. (2005)
Nucleic Acids Res. 33, e28
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F. Catez, M. Erard, N. Schaerer-Uthurralt, K. Kindbeiter, J.-J. Madjar, and J.-J. Diaz (2002)
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