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Science 2 July 1999:
Vol. 285. no. 5424, pp. 21 - 22
DOI: 10.1126/science.285.5424.21a
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News of the Week

HUMAN GENOME:
A Good SNP May Be Hard to Find

Michael Hagmann

Academic and corporate labs alike are mining the human genome for minute differences between individuals called single-nucleotide polymorphisms (SNPs). Many researchers hope that random collections of these mutations will yield a shortcut to identifying the genes underlying such major diseases as asthma or cancer. New findings suggest, however, that the payoff may be slow, because the SNPs that directly influence disease risk are scarce.

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Science. ISSN 0036-8075 (print), 1095-9203 (online)