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Science 14 May 1999:
Vol. 284. no. 5417, pp. 1135 - 1137
DOI: 10.1126/science.284.5417.1135
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Perspectives

IMMUNOLOGY:
GAD, a Single Autoantigen for Diabetes

Harald von Boehmer and Adelaida Sarukhan

The destruction of the insulin-producing b-islet cells of the pancreas by the immune system results in the development of type I diabetes. In their Perspective, von Boehmer and Sarukhan discuss the elegant demonstration in this issue (Yoon et al.) that the initiating autoantigen in this cascade of cell destruction is glutamic acid decarboxylase (GAD). They go on to propose new therapeutic strategies to treat autoimmune diabetes based on inducing tolerance to the GAD antigen in individuals susceptible to developing the disease.

The authors are at INSERM U373, Faculte Necker, 75015 Paris, France. E-mail: sarukhan{at}infobiogen.fr

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THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
A Comprehensive, Statistically Powered Analysis of GAD2 in Type 1 Diabetes.
G. C.L. Johnson, F. Payne, S. Nutland, H. Stevens, E. Tuomilehto-Wolf, J. Tuomilehto, and J. A. Todd (2002)
Diabetes 51, 2866-2870
   Abstract »    Full Text »    PDF »
A Glutamic Acid Decarboxylase 65-Specific Th2 Cell Clone Immunoregulates Autoimmune Diabetes in Nonobese Diabetic Mice.
R. Tisch, B. Wang, M. A. Atkinson, D. V. Serreze, and R. Friedline (2001)
J. Immunol. 166, 6925-6936
   Abstract »    Full Text »    PDF »
Induction of autoantibodies to the adrenal cortex and pancreatic islet cells by interferon alpha therapy for chronic hepatitis C.
B Wesche, E Jaeckel, C Trautwein, H Wedemeyer, A Falorni, H Frank, A von zur Muhlen, M-P Manns, and G Brabant (2001)
Gut 48, 378-383
   Abstract »    Full Text »    PDF »
Antigen-Specific Mediated Suppression of {{beta}} Cell Autoimmunity by Plasmid DNA Vaccination.
R. Tisch, B. Wang, D. J. Weaver, B. Liu, T. Bui, J. Arthos, and D. V. Serreze (2001)
J. Immunol. 166, 2122-2132
   Abstract »    Full Text »    PDF »
Alternative Splicing of GAD67 Results in the Synthesis of a Third Form of Glutamic-acid Decarboxylase in Human Islets and Other Non-neural Tissues.
S. D. Chessler and A. Lernmark (2000)
J. Biol. Chem. 275, 5188-5192
   Abstract »    Full Text »    PDF »
Autoantigen May Trigger Type 1 Diabetes.
(1999)
Journal Watch (General) 1999, 4
   Full Text »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)