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Science 16 April 1999:
Vol. 284. no. 5413, pp. 406 - 407
DOI: 10.1126/science.284.5413.406
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News of the Week

GENOMICS:
Drug Firms to Create Public Database of Genetic Mutations

Eliot Marshall

This week, 10 large pharmaceutical companies and a British charity announced that they will spend $45 million to create an archive of human genetic variation--and give it away. To avoid having to buy multiple, private data collections from the half-dozen or so biotech firms that are already collecting what are known as single nucleotide polymorphisms or SNPs--single-base variations that can serve as physical landmarks along the 3 billion bases of the human genome--these fiercely competitive companies are teaming up to bankroll work by a network of academic labs. The collaboration will release proprietary data free of charge to all comers by publishing it every quarter on the Internet, organizers say, no strings attached.

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THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
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Statistical prediction of single-stranded regions in RNA secondary structure and application to predicting effective antisense target sites and beyond.
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J. A. Prince, L. Feuk, W. M. Howell, M. Jobs, T. Emahazion, K. Blennow, and A. J. Brookes (2001)
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A SNP Resource for Human Chromosome 22: Extracting Dense Clusters of SNPs From the Genomic Sequence.
E. Dawson, Y. Chen, S. Hunt, L. J. Smink, A. Hunt, K. Rice, S. Livingston, S. Bumpstead, R. Bruskiewich, P. Sham, et al. (2001)
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Full flexibility genotyping of single nucleotide polymorphisms by the GOOD assay.
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New Target Regions for Human Hypertension via Comparative Genomics.
M. Stoll, A. E. Kwitek-Black, A. W. Cowley Jr., E. L. Harris, S. B. Harrap, J. E. Krieger, M. P. Printz, A. P. Provoost, J. Sassard, and H. J. Jacob (2000)
Genome Res. 10, 473-482
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A Microsphere-Based Assay for Multiplexed Single Nucleotide Polymorphism Analysis Using Single Base Chain Extension.
J. Chen, M. A. Iannone, M.-S. Li, J. D. Taylor, P. Rivers, A. J. Nelsen, K. A. Slentz-Kesler, A. Roses, and M. P. Weiner (2000)
Genome Res. 10, 549-557
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A novel procedure for efficient genotyping of single nucleotide polymorphisms.
S. Sauer, D. Lechner, K. Berlin, H. Lehrach, J.-L. Escary, N. Fox, and I. G. Gut (2000)
Nucleic Acids Res. 28, e13
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High-Throughput SNP Allele-Frequency Determination in Pooled DNA Samples by Kinetic PCR.
S. Germer, M. J. Holland, and R. Higuchi (2000)
Genome Res. 10, 258-266
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Flexible Use of High-Density Oligonucleotide Arrays for Single-Nucleotide Polymorphism Discovery and Validation.
S. Dong, E. Wang, L. Hsie, Y. Cao, X. Chen, and T. R. Gingeras (2001)
Genome Res. 11, 1418-1424
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Why FRET over genomics?.
D. A. DE ANGELIS (1999)
Physiol Genomics 1, 93-99
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