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Science 19 March 1999:
Vol. 283. no. 5409, p. 1831
DOI: 10.1126/science.283.5409.1831
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News of the Week

CANCER RESEARCH:
A Surprising Partner for Angiostatin

Marcia Barinaga

The proteins angiostatin and endostatin have generated a lot of excitement in the past year or two because of reports that they can stop or slow cancer growth in mice, apparently by preventing the birth of new blood vessels needed to nourish growing tumors. But protein drugs can be fragile and hard to produce, and efforts to get around these problems by developing small molecules that would mimic the effects of these proteins have been handicapped because little is known about how they act. Now, a research team reports in the 16 March issue of the Proceedings of the National Academy of Sciences that angiostatin binds to a surprising target on the surface of the endothelial cells responsible for blood vessel growth: an enzyme called adenosine triphosphate synthase, never before found on the outer membranes of normal cells. The binding appears to be needed for angiostatin's antigrowth effects, and ATP synthase may thus be a target for anticancer drugs that work by inhibiting blood vessel formation.

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THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Interaction of the C-terminal Domain of p43 and the alpha Subunit of ATP Synthase. ITS FUNCTIONAL IMPLICATION IN ENDOTHELIAL CELL PROLIFERATION.
S. Y. Chang, S. G. Park, S. Kim, and C.-Y. Kang (2002)
J. Biol. Chem. 277, 8388-8394
   Abstract »    Full Text »    PDF »
Adenoviral Vector Expressing Murine Angiostatin Inhibits a Model of Breast Cancer Metastatic Growth in the Lungs of Mice.
S. Gyorffy, K. Palmer, and J. Gauldie (2001)
Am. J. Pathol. 159, 1137-1147
   Abstract »    Full Text »    PDF »
Combined Treatment of a Murine Breast Cancer Model with Type 5 Adenovirus Vectors Expressing Murine Angiostatin and IL-12: A Role for Combined Anti-Angiogenesis and Immunotherapy.
S. Gyorffy, K. Palmer, T. J. Podor, M. Hitt, and J. Gauldie (2001)
J. Immunol. 166, 6212-6217
   Abstract »    Full Text »    PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)