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Science 26 February 1999:
Vol. 283. no. 5406, pp. 1250 - 1251
DOI: 10.1126/science.283.5406.1250
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News Focus

CANCER THERAPY:
Behind the Headlines of Endostatin's Ups and Downs

Jon Cohen

Researchers have been trying for a year to replicate remarkable experiments in mice, in which a compound called endostatin hampered the growth of blood vessels that feed tumors, making cancer disappear. The experiments and the attempts to repeat them have sparked reports of a "miracle cure" one day and a "failure" the next. Behind this confusing array of stories lies a scientific saga that emphasizes how small differences in techniques, reagents, and assays can foil attempts by one lab to repeat the work of another. It shows that replication, a cornerstone of the scientific process, means different things to different people. And it also helps clarify why the media-driven frenzy about endostatin has been so confusing and frustrating to the public and scientists alike.

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THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Phase I Pharmacokinetic and Pharmacodynamic Study of Recombinant Human Endostatin in Patients With Advanced Solid Tumors.
J. P. Thomas, R. Z. Arzoomanian, D. Alberti, R. Marnocha, F. Lee, A. Friedl, K. Tutsch, A. Dresen, P. Geiger, J. Pluda, et al. (2003)
J. Clin. Oncol. 21, 223-231
   Abstract »    Full Text »    PDF »
Liposome-delivered Angiostatin Strongly Inhibits Tumor Growth and Metastatization in a Transgenic Model of Spontaneous Breast Cancer.
M. G. Sacco, M. Caniatti, E. M. Catò, A. Frattini, G. Chiesa, R. Ceruti, F. Adorni, L. Zecca, E. Scanziani, and P. Vezzoni (2000)
Cancer Res. 60, 2660-2665
   Abstract »    Full Text »


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