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Science 29 January 1999:
Vol. 283. no. 5402, pp. 650 - 651
DOI: 10.1126/science.283.5402.650
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Perspectives

SIGNAL TRANSDUCTION:
The Path to Specificity

Charles S. Zuker and Rama Ranganathan

A major challenge in the study of intracellular signaling has been the elucidation of the physical and biological principles by which the network of signaling molecules is assembled to execute signaling programs. In their Perspective, Zuker et al. address recent work focusing on the organization of signaling components into macromolecular assemblies, in particular, the tyrosine kinase and G protein-coupled receptor pathways.

C. S. Zuker is at the Howard Hughes Medical Institute, Departments of Biology and Neurosciences, University of California, San Diego, CA 92093-0649, USA. E-mail: charles{at}flyeye.ucsd.edu. R. Ranganathan is in the Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX 75235-9050, USA. E-mail: rama{at}chop.swmed.edu.

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Science. ISSN 0036-8075 (print), 1095-9203 (online)