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Science 22 January 1999:
Vol. 283. no. 5401, pp. 496 - 497
DOI: 10.1126/science.283.5401.496
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Perspectives

NEUROSCIENCE:
Energy on Demand

Pierre J. Magistretti, Luc Pellerin, Douglas L. Rothman, Robert G. Shulman

New imaging techniques can see into the functioning brain, revealing the regions that are active during certain tasks and sensations. Magistretti et al., in their Perspective, take this notion one step further and, by careful analysis of the biochemistry that gives rise to imaging signals, they deduce some of the cellular and molecular events that accompany neuronal activity in the working brain, ultimately laying the groundwork for determining the biochemistry that underlies human cognition.

P. J. Magistretti and L. Pellerin are at the Institut de Physiologie, University of Lausanne, CH-1005 Lausanne, Switzerland. E-mail: pierre.magistretti{at}iphysiol.unil.ch.. R. G. Shulman is in the Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT 06520, USA. D. L. Rothman is in the Diagnostic Radiology Deparmtent, Yale University, New Haven, CT 06520, USA.

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Regulation of Glutamate Transporter Function.
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Neuroscientist 5, 280-282
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Determination of the rate of the glutamate/glutamine cycle in the human brain by in vivo 13C NMR.
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Cerebral energetics and the glycogen shunt: Neurochemical basis of functional imaging.
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