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Science 4 December 1998:
Vol. 282. no. 5395, pp. 1842 - 1843
DOI: 10.1126/science.282.5395.1842

Perspectives

BIOCHEMISTRY:
Biological Hydrogen Production: Not So Elementary

Michael W. W. Adams and Edward I. Stiefel

Many organisms metabolize hydrogen gas by means of an enzyme called hydrogenase. The nature of the catalytic sites in the hydrogenases has long been a subject of conjecture and debate. In their Perspective, Adams and Stiefel discuss results reported in the same issue by Peters et al. in which x-ray crystallography was used to provide the first structural glimpse of the iron-only hydrogenase from the hydrogen-producing, anaerobic bacterium Clostridium pasteurianum. With this information, it is hoped that the properties of the hydrogenase enzyme can now be understood and possibly mimicked for chemical processing applications.


M. W. W. Adams is in the Department of Biochemistry and Molecular Biology, University of Georgia, Athens, GA 30602, USA. E-mail: adams{at}bmb.uga.edu. E. I. Stiefel is in Corporate Research, Exxon Research and Engineering Company, Clinton Township, Annandale, NJ 08801, USA. E-mail: eistief{at}erenj.com.

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B. K. Semin, L. N. Davletshina, A. A. Novakova, T.'y. Y. Kiseleva, V. Y. Lanchinskaya, A. Y. Aleksandrov, N. Seifulina, I.'y. I. Ivanov, M. Seibert, and A. B. Rubin (2003)
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Science. ISSN 0036-8075 (print), 1095-9203 (online)