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Science 27 November 1998:
Vol. 282. no. 5394, pp. 1654 - 1657
DOI: 10.1126/science.282.5394.1654
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Perspectives

NEUROSCIENCE:
The When and Where of Floor Plate Induction

Jane Dodd, Thomas M. Jessell, Marysia Placzek

Floor plate induction is a well-studied early step in the development of the nervous system. Here Dodd, Jessell, and Placzek review recent work on the mechanism of that induction, including some controversial suggestions that part of the floor plate is derived from notochord.

J. Dodd is in the Department of Physiology and Cellular Biophysics and Center for Neurobiology and Behavior, Columbia University, New York, NY 10032, USA. T. M. Jessell is at the Howard Hughes Medical Institute, Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY 10032, USA. E-mail: tmj1{at}columbia.edu. M. Placzek is in the Developmental Genetics Programme, Krebs Institute, University of Sheffield, Sheffield S10 2TN, UK.

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