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Science 27 November 1998:
Vol. 282. no. 5394, p. 1609
DOI: 10.1126/science.282.5394.1609r
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The hox genes, which are so critical for pattern specification during development, are aligned in clusters on the chromosomes. Although lower chordates have only one cluster, tetrapods have four, and, as now shown by Amores et al., (p. 1711) zebrafish have seven. The additional clusters likely arose early in the evolution of fishes, perhaps by whole genome duplication, and may have provided the tools to support the diversification of fishes.




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Science. ISSN 0036-8075 (print), 1095-9203 (online)