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Science 6 November 1998:
Vol. 282. no. 5391, pp. 1061 - 1062
DOI: 10.1126/science.282.5391.1061
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Perspectives

CELL BIOLOGY:
New Potential for Human Embryonic Stem Cells

John Gearhart

Cells taken at a stage of embryo development have the potential to differentiate into all of the different tissue types of an organism. These embryonic stem (ES) cells are therefore of great interest in possible transplant therapies for genetic disease. ES cells have previously been obtained from some mammalian species, but not others. In his Perspective, Gearhart discusses a report in the same issue by Thomson et al. in which the successful derivation of ES cell lines from human cells is described. This achievement may open doors to genetic therapy, but additional research and resolution of practical issues will be necessary. As Gearhart describes, one such issue is the current prohibition by U.S. federal law of federally funded research on embryonic cells, and this legislation will need to be reexamined in light of these new developments.

The author is in the Department of Gynecology and Obstetrics, Johns Hopkins Medicine, Baltimore, MD 21287, USA. E-mail: gearhart{at}jhmi.edu

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Bulk vitrification of human embryonic stem cells.
T. Li, C. Zhou, C. Liu, Q. Mai, and G. Zhuang (2008)
Hum. Reprod. 23, 358-364
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Cryopreservation of human embryonic stem cells without the use of a programmable freezer.
S. Y. Ha, B. C. Jee, C. S. Suh, H. S. Kim, S. K. Oh, S. H. Kim, and S. Y. Moon (2005)
Hum. Reprod. 20, 1779-1785
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Can stem cells mend a broken heart?.
S. Davani, F. Deschaseaux, D. Chalmers, P. Tiberghien, and J.-P. Kantelip (2005)
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Stem Cells 22, 950-961
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Death, dying and donation: organ transplantation and the diagnosis of death.
I H Kerridge, P Saul, M Lowe, J McPhee, and D Williams (2002)
J. Med. Ethics 28, 89-94
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Effective cryopreservation of human embryonic stem cells by the open pulled straw vitrification method.
B.E. Reubinoff, M.F. Pera, G. Vajta, and A.O. Trounson (2001)
Hum. Reprod. 16, 2187-2194
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The Ethics of Embryonic Stem Cells--Now and Forever, Cells Without End.
E. Juengst and M. Fossel (2000)
JAMA 284, 3180-3184
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In vivo immunological function of mast cells derived from embryonic stem cells: An approach for the rapid analysis of even embryonic lethal mutations in adult mice in vivo.
M. Tsai, J. Wedemeyer, S. Ganiatsas, S.-Y. Tam, L. I. Zon, and S. J. Galli (2000)
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In vivo immunological function of mast cells derived from embryonic stem cells: An approach for the rapid analysis of even embryonic lethal mutations in adult mice in vivo.
M. Tsai, J. Wedemeyer, S. Ganiatsas, S.-Y. Tam, L. I. Zon, and S. J. Galli (2000)
PNAS 97, 9186-9190
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Science. ISSN 0036-8075 (print), 1095-9203 (online)