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Science 6 November 1998:
Vol. 282. no. 5391, pp. 1059 - 1060
DOI: 10.1126/science.282.5391.1059
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Perspectives

ION CHANNELS:
Exciting Times for PIP2

Frances M. Ashcroft

One class of potassium channels, the KATP channels, are key players in a variety of functions-insulin secretion, blood vessel tone, and the response of the heart to lack of oxygen. Ashcroft describes in her Perspective how new results in this issue explain a long-standing puzzle about the true sensitivity of these channels to ATP. Baukrowitz et al. and Shyng et al. show that the phospholipid PIP2 regulates the ATP sensitivity of these channels.

The author is at the University Laboratory of Physiology, Oxford OX1 3PT, UK. E-mail: frances.ashcroft{at}physiol.ox.ac.uk

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THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Modeling transmural heterogeneity of KATP current in rabbit ventricular myocytes.
A. Michailova, W. Lorentz, and A. McCulloch (2007)
Am J Physiol Cell Physiol 293, C542-C557
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Acute Regulation of Epithelial Sodium Channel by Anionic Phospholipids.
H.-P. Ma and D. C. Eaton (2005)
J. Am. Soc. Nephrol. 16, 3182-3187
   Abstract »    Full Text »    PDF »
Membrane Phosphoinositides Control Insulin Secretion Through Their Effects on ATP-Sensitive K+ Channel Activity.
C.-W. Lin, F. Yan, S. Shimamura, S. Barg, and S.-L. Shyng (2005)
Diabetes 54, 2852-2858
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Phosphorylated inositol compounds in beta -cell stimulus-response coupling.
C. J. Barker, I. B. Leibiger, B. Leibiger, and P.-O. Berggren (2002)
Am J Physiol Endocrinol Metab 283, E1113-E1122
   Abstract »    Full Text »    PDF »
Anionic Phospholipids Regulate Native and Expressed Epithelial Sodium Channel (ENaC).
H.-P. Ma, S. Saxena, and D. G. Warnock (2002)
J. Biol. Chem. 277, 7641-7644
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Intracellular Ca2+ Modulation of ATP-Sensitive K+ Channel Activity in Acetylcholine-Induced Activation of Rat Pancreatic {beta}-Cells.
K. Nakano, S. Suga, T. Takeo, Y. Ogawa, T. Suda, T. Kanno, and M. Wakui (2002)
Endocrinology 143, 569-576
   Abstract »    Full Text »    PDF »
Modulation of nucleotide sensitivity of ATP-sensitive potassium channels by phosphatidylinositol-4-phosphate 5-kinase.
S.-L. Shyng, A. Barbieri, A. Gumusboga, C. Cukras, L. Pike, J. N. Davis, P. D. Stahl, and C. G. Nichols (2000)
PNAS 97, 937-941
   Abstract »    Full Text »    PDF »
Salinity and Hyperosmotic Stress Induce Rapid Increases in Phosphatidylinositol 4,5-Bisphosphate, Diacylglycerol Pyrophosphate, and Phosphatidylcholine in Arabidopsis thaliana Cells.
C. Pical, T. Westergren, S. K. Dove, C. Larsson, and M. Sommarin (1999)
J. Biol. Chem. 274, 38232-38240
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Glucose Regulation of Free Ca2+ in the Endoplasmic Reticulum of Mouse Pancreatic Beta Cells.
A. Tengholm, B. Hellman, and E. Gylfe (1999)
J. Biol. Chem. 274, 36883-36890
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Regulation of the ROMK channel: interaction of the ROMK with associate proteins.
W. Wang (1999)
Am J Physiol Renal Physiol 277, F826-F831
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Phospholipase C Binds to the Receptor-like GPR1 Protein and Controls Pseudohyphal Differentiation in Saccharomyces cerevisiae.
K. Ansari, S. Martin, M. Farkasovsky, I.-M. Ehbrecht, and H. Kuntzel (1999)
J. Biol. Chem. 274, 30052-30058
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Science. ISSN 0036-8075 (print), 1095-9203 (online)