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Science 16 October 1998:
Vol. 282. no. 5388, p. 377
DOI: 10.1126/science.282.5388.377l
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To start an immune response, dendritic cells pick up antigen and travel with it to the lymph nodes, where they come in contact with lymphocytes. Where, then, do the dendritic cells come from? Monocytes cultured in vitro with certain cytokines can differentiate into dendritic cells in about 1 week. Randolph et al. (p. 480; see the Perspective by Shortman and Maraskovsky) found that monocytes cultured for 2 days with a monolayer of endothelial cells and particles for phagocytosis will beget a population of dendritic cells that reemerge from beneath the monolayer. Thus, the source of dendritic cells may be blood monocytes that are exposed to particulate stimuli in the subendothelial milieu.




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Science. ISSN 0036-8075 (print), 1095-9203 (online)