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Science 16 October 1998:
Vol. 282. no. 5388, p. 377
DOI: 10.1126/science.282.5388.377j
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This Week in Science

The success of "naked" DNA in inducing antibody or T cell responses in animal models has sparked hope that it will be an important new method of vaccine delivery. Although DNA vaccines have been tested in HIV-infected individuals, their immune status is so abnormal that the results could not be extrapolated to normal individuals. As a step toward making an effective vaccine for malaria, Wang et al. (p. 476) demonstrate that DNA encoding the Plasmodium falciparum circumsporozoite protein induces a cytotoxic T cell response in healthy human volunteers.




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Science. ISSN 0036-8075 (print), 1095-9203 (online)