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Science 2 October 1998:
Vol. 282. no. 5386, p. 9
DOI: 10.1126/science.282.5386.9p
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This Week in Science

Cytolytic T lymphocytes (CTLs) destroy cells that are infected by viruses or intracellular bacteria. This destruction lyses the cells but can also free the bacteria. The subset of CTLs that releases granules to kill infected cells also can damage the bacteria harbored within. Stenger et al. (p. 121) show that the protein granulysin, which is a component of the granule, can kill bacteria, including the mycobacteria that cause tuberculosis and hide inside cells. The identification of a natural antimicrobial contained in T cell granules identifies a mechanism that T cells use to clear intracellular pathogens.




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Science. ISSN 0036-8075 (print), 1095-9203 (online)