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Science 11 September 1998:
Vol. 281. no. 5383, pp. 1581 - 1582
DOI: 10.1126/science.281.5383.1581a
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News of the Week

BIOLOGY:
RNA-Splicing Machinery Revealed

Dan Ferber

A European group has paired a new high-speed technique for analyzing proteins with a database of partial gene sequences to identify 44 components of the human spliceosome. Researchers had previously identified only about half of the proteins in the spliceosome, a multiprotein machine that splices the noncoding sequences out of newly minted RNAs to produce messenger RNAs, the cell's templates for protein production. The feat also provided additional proof of the worth of the database of human gene fragments called "expressed sequence tags," which some genome experts once dismissed as a poor substitute for the complete gene sequences to come from the Human Genome Project.

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Science. ISSN 0036-8075 (print), 1095-9203 (online)