Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Science 24 July 1998:
Vol. 281. no. 5376, pp. 507 - 509
DOI: 10.1126/science.281.5376.507
Prev | Table of Contents | Next

News Focus

NEUROGENETICS:
New Gene Tied to Common Form of Alzheimer's

Jean Marx

A common mutation in the gene encoding a protein called a2-macroglobulin appears to increase the risk of the most common form of Alzheimer's disease, which occurs late in life. The number of Alzheimer's cases linked to the mutation could potentially be large, given that an estimated 30% of the population carries the mutation. The new gene and its protein, which may help scour toxins from between neurons, could also make sense of how several other proteins already implicated in Alzheimer's might contribute to the disease.

Read the Full Text


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Risk Factors for Alzheimer's Disease: Role of Multiple Antioxidants, Non-Steroidal Anti-inflammatory and Cholinergic Agents Alone or in Combination in Prevention and Treatment.
K. N. Prasad, W. C. Cole, and K. C. Prasad (2002)
J. Am. Coll. Nutr. 21, 506-522
   Abstract »    Full Text »    PDF »
No association of alpha-2 macroglobulin gene five-nucleotide deletion with AD in Taiwan Chinese.
C.-J. Hu, S.-M. Sung, H.-C. Liu, K.-Y. Lee, W.-C. Hsu, W.-K. Wong, C.-C. Lee, C.-H. Tsai, and J.-G. Chang (1999)
Neurology 53, 642
   Abstract »    Full Text »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)