Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.
Applied Biosytems - Introducing Silencer Select siRNAs

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Science 15 May 1998:
Vol. 280. no. 5366, pp. 1035 - 1036
DOI: 10.1126/science.280.5366.1035
Prev | Table of Contents | Next

Research Commentaries

CELL CYCLE:
The Expanding Role of Cell Cycle Regulators

Tyler Jacks and Robert A. Weinberg

The cell cycle is a complex series of protein interactions and enzymatic alterations that governs the orderly division of cells. Jacks and Weinberg summarize new evidence--some of which is presented by Di Cunto et al. in this issue--that the proteins that make up the cell cycle machinery can also have other functions, often in directing the differentiation of cells.

T. Jacks is in the Department of Biology and the Center for Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02142, USA. R. A. Weinberg is in the Department of Biology and the Whitehead Institute for Biomedical Research, Massachusetts Institute of Technology, Cambridge, MA 02142, USA. E-mail: tjacks{at}mit.edu, weinberg{at}wi.mit.edu

Read the Full Text


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Epistatic Relationship between the Cancer Susceptibility Genes CHEK2 and p27.
C. Cybulski, B. Gliniewicz, A. Sikorski, J. Kladny, T. Huzarski, J. Gronwald, T. Byrski, T. Debniak, B. Gorski, A. Jakubowska, et al. (2007)
Cancer Epidemiol. Biomarkers Prev. 16, 572-576
   Abstract »    Full Text »    PDF »
Effect of Retinoic Acid on Gene Expression in Human Conjunctival Epithelium: Secretory Phospholipase A2 Mediates Retinoic Acid Induction of MUC16.
Y. Hori, S. J. Spurr-Michaud, C. L. Russo, P. Argueso, and I. K. Gipson (2005)
Invest. Ophthalmol. Vis. Sci. 46, 4050-4061
   Abstract »    Full Text »    PDF »
Cyclin-dependent Kinase Inhibitors and JNK Act as Molecular Switches, Regulating the Choice between Growth Arrest and Apoptosis Induced by Galectin-8.
R. Arbel-Goren, Y. Levy, D. Ronen, and Y. Zick (2005)
J. Biol. Chem. 280, 19105-19114
   Abstract »    Full Text »    PDF »
Calcium Sensing Receptor in Human Colon Carcinoma: Interaction with Ca2+ and 1,25-Dihydroxyvitamin D3.
S. Chakrabarty, H. Wang, L. Canaff, G. N. Hendy, H. Appelman, and J. Varani (2005)
Cancer Res. 65, 493-498
   Abstract »    Full Text »    PDF »
Interplay between HIV-1 Vpr and Sp1 Modulates p21WAF1 Gene Expression in Human Astrocytes.
S. Amini, M. Saunders, K. Kelley, K. Khalili, and B. E. Sawaya (2004)
J. Biol. Chem. 279, 46046-46056
   Abstract »    Full Text »    PDF »
Control of Smooth Muscle Cell Activation.
G. Gabbiani (2004)
Arterioscler. Thromb. Vasc. Biol. 24, 804-805
   Full Text »
Cell Cycle-Dependent Regulation of Smooth Muscle Cell Activation.
R. C. Braun-Dullaeus, M. J. Mann, D. G. Sedding, S. W. Sherwood, H. E. von der Leyen, and V. J. Dzau (2004)
Arterioscler. Thromb. Vasc. Biol. 24, 845-850
   Abstract »    Full Text »
Distinct and nonoverlapping roles for pRB and cyclin D:cyclin-dependent kinases 4/6 activity in melanocyte survival.
B. D. Yu, M. Becker-Hapak, E. L. Snyder, M. Vooijs, C. Denicourt, and S. F. Dowdy (2003)
PNAS 100, 14881-14886
   Abstract »    Full Text »    PDF »
Platelet-derived Growth Factor (PDGF) Receptor-{alpha}-activated c-Jun NH2-terminal Kinase-1 Is Critical for PDGF-induced p21WAF1/CIP1 Promoter Activity Independent of p53.
J. Yu, X.-W. Liu, and H.-R. C. Kim (2003)
J. Biol. Chem. 278, 49582-49588
   Abstract »    Full Text »    PDF »
Cell Context-Dependent Differences in the Induction of E2F-1 Gene Expression by 17{beta}-Estradiol in MCF-7 and ZR-75 Cells.
S. Ngwenya and S. Safe (2003)
Endocrinology 144, 1675-1685
   Abstract »    Full Text »    PDF »
Rules for Making Human Tumor Cells.
W. C. Hahn and R. A. Weinberg (2002)
N. Engl. J. Med. 347, 1593-1603
   Full Text »    PDF »
Molecular Signaling in Bioengineered Tissue Microenvironments.
D. P. BOTTARO, A. LIEBMANN-VINSON, and M. A. HEIDARAN (2002)
Ann. N.Y. Acad. Sci. 961, 143-153
   Abstract »    Full Text »    PDF »
Human Immunodeficiency Virus and Malignancy: Thoughts on Viral Oncogenesis.
W. P. Schecter (2001)
Arch Surg 136, 1419-1425
   Full Text »    PDF »
p21waf correlates with DNA replication but not with prognosis in invasive breast cancer.
U-J Gohring, A Bersch, M Becker, W Neuhaus, and T Schondorf (2001)
J. Clin. Pathol. 54, 866-870
   Abstract »    Full Text »    PDF »
The Selection for Mismatch Repair Defects in Hereditary Nonpolyposis Colorectal Cancer: Revising the Mutator Hypothesis.
R. Fishel (2001)
Cancer Res. 61, 7369-7374
   Full Text »    PDF »
The Retinoblastoma Gene Regulates Somatic Growth during Mouse Development.
A. Yu. Nikitin, B. Shan, A. Flesken-Nikitin, K.-H. Chang, and W.-H. Lee (2001)
Cancer Res. 61, 3110-3118
   Abstract »    Full Text »
Coordinate Control of Muscle Cell Survival by Distinct Insulin-like Growth Factor Activated Signaling Pathways.
M. A. Lawlor and P. Rotwein (2000)
J. Cell Biol. 151, 1131-1140
   Abstract »    Full Text »    PDF »
Insulin-Like Growth Factor-Mediated Muscle Cell Survival: Central Roles for Akt and Cyclin-Dependent Kinase Inhibitor p21.
M. A. Lawlor and P. Rotwein (2000)
Mol. Cell. Biol. 20, 8983-8995
   Abstract »    Full Text »
Chemoprotective effects of KF41399, a derivative of carbazole compounds, on nimustine-induced thrombocytopenia.
Y. Shiotsu, K. Yamashita, F. Kanai, Y. Ikuina, C. Murakata, M. Teramura, H. Mizoguchi, T. Tamaoki, and S. Akinaga (2000)
Blood 95, 3771-3780
   Abstract »    Full Text »    PDF »
Downregulation of 14-3-3{sigma} Prevents Clonal Evolution and Leads to Immortalization of Primary Human Keratinocytes.
E. Dellambra, O. Golisano, S. Bondanza, E. Siviero, P. Lacal, M. Molinari, S. D'Atri, and M. De Luca (2000)
J. Cell Biol. 149, 1117-1130
   Abstract »    Full Text »    PDF »
Overexpression of Kinase-Associated Phosphatase (KAP) in Breast and Prostate Cancer and Inhibition of the Transformed Phenotype by Antisense KAP Expression.
S. W. Lee, C. L. Reimer, L. Fang, M. L. Iruela-Arispe, and S. A. Aaronson (2000)
Mol. Cell. Biol. 20, 1723-1732
   Abstract »    Full Text »
c-Jun Transactivates the Promoter of the Human p21WAF1/Cip1 Gene by Acting as a Superactivator of the Ubiquitous Transcription Factor Sp1.
D. Kardassis, P. Papakosta, K. Pardali, and A. Moustakas (1999)
J. Biol. Chem. 274, 29572-29581
   Abstract »    Full Text »    PDF »
Loss of Cell Cycle Regulators p27Kip1 and Cyclin E in Transitional Cell Carcinoma of the Bladder Correlates with Tumor Grade and Patient Survival.
J. J. Del Pizzo, A. Borkowski, S. C. Jacobs, and N. Kyprianou (1999)
Am. J. Pathol. 155, 1129-1136
   Abstract »    Full Text »    PDF »
Retinoic Acid Promotes Ubiquitination and Proteolysis of Cyclin D1 during Induced Tumor Cell Differentiation.
M. J. Spinella, S. J. Freemantle, D. Sekula, J. H. Chang, A. J. Christie, and E. Dmitrovsky (1999)
J. Biol. Chem. 274, 22013-22018
   Abstract »    Full Text »    PDF »
RB-mediated suppression of spontaneous multiple neuroendocrine neoplasia and lung metastases in Rb+/- mice.
A. Yu. Nikitin, M. I. Juarez-Perez, S. Li, L. Huang, and W.-H. Lee (1999)
PNAS 96, 3916-3921
   Abstract »    Full Text »    PDF »
p27kip1: A Multifunctional Cyclin-Dependent Kinase Inhibitor with Prognostic Significance in Human Cancers.
R. V. Lloyd, L. A. Erickson, L. Jin, E. Kulig, X. Qian, J. C. Cheville, and B. W. Scheithauer (1999)
Am. J. Pathol. 154, 313-323
   Abstract »    Full Text »    PDF »
A Paradigm for Cancer Treatment Using the Retinoblastoma Gene in a Mouse Model.
A. YU. NIKITIN, D. J. RILEY, and W.-H. LEE (1999)
Ann. N.Y. Acad. Sci. 886, 12-22
   Abstract »    Full Text »    PDF »
Convergence of Progesterone and Epidermal Growth Factor Signaling in Breast Cancer. POTENTIATION OF MITOGEN-ACTIVATED PROTEIN KINASE PATHWAYS.
C. A. Lange, J. K. Richer, T. Shen, and K. B. Horwitz (1998)
J. Biol. Chem. 273, 31308-31316
   Abstract »    Full Text »    PDF »
A Pure Estrogen Antagonist Inhibits Cyclin E-Cdk2 Activity in MCF-7 Breast Cancer Cells and Induces Accumulation of p130-E2F4 Complexes Characteristic of Quiescence.
J. S. Carroll, O. W. J. Prall, E. A. Musgrove, and R. L. Sutherland (2000)
J. Biol. Chem. 275, 38221-38229
   Abstract »    Full Text »    PDF »
Sp1 Plays a Critical Role in the Transcriptional Activation of the Human Cyclin-dependent Kinase Inhibitor p21WAF1/Cip1 Gene by the p53 Tumor Suppressor Protein.
G. Koutsodontis, I. Tentes, P. Papakosta, A. Moustakas, and D. Kardassis (2001)
J. Biol. Chem. 276, 29116-29125
   Abstract »    Full Text »    PDF »
5-Hydroxytryptamine 2B receptor regulates cell-cycle progression: Cross-talk with tyrosine kinase pathways.
C. G. Nebigil, J.-M. Launay, P. Hickel, C. Tournois, and L. Maroteaux (2000)
PNAS 97, 2591-2596
   Abstract »    Full Text »    PDF »


ADVERTISEMENT
Click Me!

ADVERTISEMENT
Click Me!

To Advertise     Find Products