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Science 27 March 1998:
Vol. 279. no. 5359, p. 2042
DOI: 10.1126/science.279.5359.2042
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Research News

DEVELOPMENTAL BIOLOGY:
Receptor Links Blood Vessels, Axons

Wade Roush

In the 20 March issue of Cell, a group of biochemists reports that it has identified a new receptor molecule on the endothelial cells that line blood vessels. The receptor, called neuropilin, picks up a signal from VEGF, a protein made by tissues--including cancerous tumors--that need new blood vessels. The new receptor turns out to be the same one that nerve axons use to detect Semaphorin III, a protein that helps steer axons to their proper destinations in the developing nervous system, and therefore could provide researchers with a new target that might fight cancer by blocking tumor growth.

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THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Endometriosis as a neurovascular condition: estrous variations in innervation, vascularization, and growth factor content of ectopic endometrial cysts in the rat.
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Am J Physiol Regulatory Integrative Comp Physiol 294, R162-R171
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Innervation of ectopic endometrium in a rat model of endometriosis.
K. J. Berkley, N. Dmitrieva, K. S. Curtis, and R. E. Papka (2004)
PNAS 101, 11094-11098
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Methotrexate Causes Apoptosis in Postmitotic Endothelial Cells.
C. J. Merkle, I. M. Moore, B. S. Penton, B. J. Torres, R. K. Cueny, R. C. Schaeffer Jr., and D. W. Montgomery (2000)
Biol Res Nurs 2, 5-14
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Neuregulin activation of ErbB receptors in vascular endothelium leads to angiogenesis.
K. S. Russell, D. F. Stern, P. J. Polverini, and J. R. Bender (1999)
Am J Physiol Heart Circ Physiol 277, H2205-H2211
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