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Science 27 February 1998:
Vol. 279. no. 5355, p. 1307
DOI: 10.1126/science.279.5355.1307a
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AAAS MEETING:
Gene Diversity Muddles Heart Disease Story

Robert F. Service

Findings reported at the meeting suggest that healthy people have such widespread variation in one candidate heart disease gene, the gene coding for a protein called lipoprotein lipase (an enzyme that can reduce blood levels of certain fats linked to heart disease), that it is virtually impossible, for now, to tease out mutations that increase risk of the disease. Population geneticists studying one region of the gene found a high degree of variation among healthy people from three different ethnic groups, making it difficult to figure out which mutations are causal and thereby design simple genetic screens for the disease.

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Science. ISSN 0036-8075 (print), 1095-9203 (online)