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Science 13 February 1998:
Vol. 279. no. 5353, pp. 983 - 984
DOI: 10.1126/science.279.5353.983
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Research News

INFECTIOUS DISEASES:
A Method in Ebola's Madness

Ingrid Wickelgren

On page 1034, a team of molecular virologists reports results suggesting that the Ebola virus uses different versions of the same glycoprotein--a protein with sugar groups attached--to wage a two-pronged attack on the body. One glycoprotein, secreted by the virus, seems to paralyze the inflammatory response that should fight it off, while the other, which stays bound to Ebola, homes in on the endothelial cells lining the blood vessels, helping the virus infect and damage them. If confirmed in infected animals and humans, the findings suggest that these glycoproteins could be targets for anti-Ebola vaccines as well as for drugs that treat Ebola infections.

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THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Classical swine fever virus induces proinflammatory cytokines and tissue factor expression and inhibits apoptosis and interferon synthesis during the establishment of long-term infection of porcine vascular endothelial cells.
E. Bensaude, J. L. E. Turner, P. R. Wakeley, D. A. Sweetman, C. Pardieu, T. W. Drew, T. Wileman, and P. P. Powell (2004)
J. Gen. Virol. 85, 1029-1037
   Abstract »    Full Text »    PDF »
African Swine Fever Virus Infection of Porcine Aortic Endothelial Cells Leads to Inhibition of Inflammatory Responses, Activation of the Thrombotic State, and Apoptosis.
I. Vallee, S. W. G. Tait, and P. P. Powell (2001)
J. Virol. 75, 10372-10382
   Abstract »    Full Text »    PDF »
Role of Vascular Endothelial Growth Factor in Ovarian Cancer : Inhibition of Ascites Formation by Immunoneutralization.
S. Mesiano, N. Ferrara, and R. B. Jaffe (1998)
Am. J. Pathol. 153, 1249-1256
   Abstract »    Full Text »    PDF »


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