VIROLOGY:  Even Viruses Can Learn to Cope with Stress

doi:10.1126/science.279.5347.40

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Science 2 January 1998:
Vol. 279. no. 5347, pp. 40 - 41
DOI: 10.1126/science.279.5347.40

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Perspectives

VIROLOGY:
Even Viruses Can Learn to Cope with Stress

Grant McFadden

When a virus infects a cell, cellular defense mechanisms are activated, sometimes even causing cell death in an effort to stem the infection. As McFadden explains in his commentary, the virus in turn marshals its own countermeasures, striving to keep the cell alive so the virus can replicate and spread. A report in this week's issue by Schisler et al. shows how one of these countermeasures--synthesis of glutathione synthase, which protects cells against oxidative damage--is used by molluscum contagiosum virus and synthesized by a unique translation control mechanism for selenoproteins.

The author is at the John P. Robarts Research Institute and the Department of Microbiology and Immunology, University of Western Ontario, London, Ontario, Canada N6G 2V4. E-mail: mcfadden{at}rri.on.ca

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