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Science 5 December 1997:
Vol. 278. no. 5344, p. 1713
DOI: 10.1126/science.278.5344.1713
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Special News Report

IMMUNOLOGY:
Ways to Vary the Gene Vaccine Theme

Gary Taubes

When researchers first reported in Science more than 7 years ago that directly injecting DNA into a muscle could lead to the production of proteins (see main text), they concluded that the finding "may provide alternative approaches to vaccine development." That's turned out to be a classic scientific understatement: So many researchers are now developing so-called DNA vaccines that entire scientific meetings are devoted to the topic, it has its own Internet site, and biotech companies are tripping over each other to get into the business. And, as is true in any booming scientific field, researchers have come up with many creative variations on the original theme.

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THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Comparison of Humoral Immune Responses Elicited by DNA and Protein Vaccines Based on Merozoite Surface Protein-1 from Plasmodium yoelii, a Rodent Malaria Parasite.
Y. Kang, P. A. Calvo, T. M. Daly, and C. A. Long (1998)
J. Immunol. 161, 4211-4219
   Abstract »    Full Text »    PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)