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Science 26 September 1997:
Vol. 277. no. 5334, pp. 1948 - 1949
DOI: 10.1126/science.277.5334.1948
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Perspectives

DNA METHYLATION:
Tying It All Together: Epigenetics, Genetics, Cell Cycle, and Cancer

Stephen B. Baylin

The methylation state of DNA can be transferred from generation to generation of cells, qualifying this gene-regulatory event as epigenetic. In his Perspective, Baylin discusses the new link between DNA replication and DNA methylation, demonstrated in this week's issue, and speculates that this linkage is disrupted in tumor cells. On page 1996, Chuang et al. suggest that replication and methylation are linked through the binding of DNA-methyltransferase to proliferating cell nuclear antigen (PCNA).

The author is at the Johns Hopkins Comprehensive Cancer Center and the Department of Medicine, Baltimore, MD 21231, USA. E-mail: sbaylin{at}welchlink.welch.jhu.edu

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