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Science 12 September 1997:
Vol. 277. no. 5332, pp. 1605 - 1606
DOI: 10.1126/science.277.5332.1605
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Research News
CANCER GENETICS:
First p53 Relative May Be a New Tumor Suppressor
Steven Dickman
Despite being one of the most studied genes in history, the p53 tumor suppressor gene had no known relatives--until now. Researchers have identified a new gene, called p73, that not only resembles p53 structurally but may have similar functions. That, plus p73's location on a part of chromosome 1 already thought to harbor one or more tumor-suppressor genes, suggests that it, too, may play a role in inhibiting cancer development.
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THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
- The Activation Domains, the Proline-rich Domain, and the C-terminal Basic Domain in p53 Are Necessary for Acetylation of Histones on the Proximal p21 Promoter and Interaction with p300/CREB-binding Protein.
- G. Liu, T. Xia, and X. Chen (2003)
J. Biol. Chem.
278, 17557-17565
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- p73 gene alterations and expression in primary oral and laryngeal squamous carcinomas.
- A. K. El-Naggar, S. Lai, G. L. Clayman, B. Mims, S. M. Lippman, M. Coombes, M. A. Luna, and G. Lozano (2001)
Carcinogenesis
22, 729-735
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- p73 competes with p53 and attenuates its response in a human ovarian cancer cell line.
- F. Vikhanskaya, M. D'Incalci, and M. Broggini (2000)
Nucleic Acids Res.
28, 513-519
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- Deletion of the COOH-Terminal Region of p73{{alpha}} Enhances Both Its Transactivation Function and DNA-binding Activity but Inhibits Induction of Apoptosis in Mammalian Cells.
- T. Ozaki, M. Naka, N. Takada, M. Tada, S. Sakiyama, and A. Nakagawara (1999)
Cancer Res.
59, 5902-5907
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- The Molecular Pathogenesis of Corticotroph Tumors.
- P. L. M. Dahia and A. B. Grossman (1999)
Endocr. Rev.
20, 136-155
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- Inactivation of p53 but Not p73 by Adenovirus Type 5 E1B 55-Kilodalton and E4 34-Kilodalton Oncoproteins.
- J. Roth, C. Konig, S. Wienzek, S. Weigel, S. Ristea, and M. Dobbelstein (1998)
J. Virol.
72, 8510-8516
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