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Science 5 September 1997:
Vol. 277. no. 5331, p. 1439
DOI: 10.1126/science.277.5331.1439
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Research News

MOLECULAR ENDOCRINOLOGY:
Differing Roles Found for Estrogen's Two Receptors

Elizabeth Pennisi

Despite many years of study, the hormone estrogen and related compounds still remain mysterious in many ways. New findings reported on page 1508 of this issue showing that the two receptors through which estrogens exert their effects can act quite differently, depending on the particular substance binding to them, may now help explain estrogen's broad spectrum of activity and also some of the paradoxical effects of estrogenlike drugs. The results also suggest that it may be possible to develop "designer estrogens" that have more specific effects than the drugs currently in use.

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THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Differential Messenger RNA Transcription of Androgen Receptor and Estrogen Receptor in Gonad in Relation to the Sex Change in Protandrous Black Porgy, Acanthopagrus schlegeli.
C.-L. He, J.-L. Du, Y.-H. Lee, Y.-S. Huang, Y. Nagahama, and C.-F. Chang (2003)
Biol Reprod 69, 455-461
   Abstract »    Full Text »    PDF »
Are Estrogens of Import to Primate/Human Ovarian Folliculogenesis?.
S. F. Palter, A. B. Tavares, A. Hourvitz, J. D. Veldhuis, and E. Y. Adashi (2001)
Endocr. Rev. 22, 389-424
   Abstract »    Full Text »    PDF »
Human Platelets Contain a Glycosylated Estrogen Receptor {beta}.
M. L. Nealen, K. V. Vijayan, E. Bolton, and P. F. Bray (2001)
Circ. Res. 88, 438-442
   Abstract »    Full Text »    PDF »
Estrogen Mediates the Protective Effects of Pregnancy and Chorionic Gonadotropin in a Mouse Model of Vascular Injury.
L. Zhang, M. C. Fishman, and P. L. Huang (1999)
Arterioscler Thromb Vasc Biol 19, 2059-2065
   Abstract »    Full Text »    PDF »


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