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Science 29 August 1997:
Vol. 277. no. 5330, pp. 1259 - 1260
DOI: 10.1126/science.277.5330.1259
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Perspectives

GENETICS:
Yeast as a Model Organism

David Botstein, Steven A. Chervitz, and J. Michael Cherry

Yeast have many genes with homologs in humans. Has our understanding of these genes helped our understanding of human biology or disease? In his Perspective, Botstein argues "yes" and, as an example, discusses a report in this week's issue by Sinclair et al. on the yeast homolog of the gene whose dysfunction causes a disease of premature aging, Werner syndrome.

The authors are in the Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305, USA. E-mail: botstein{at}genome.stanford.edu

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