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Science 22 August 1997:
Vol. 277. no. 5329, p. 1037
DOI: 10.1126/science.277.5329.1037
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NEUROBIOLOGY:
NGF Signals Ride a Trolley to Nucleus

Marcia Barinaga

NGF Signals Ride a Trolley to Nucleus

Researchers have known for decades that nerve growth factor (NGF) is swallowed up and packaged in vesicles that travel up neuronal axons to the cell body. But no one knew just what role this "retrograde" transport played in bringing about NGF's neuron-nurturing effects. New work described on page 1097 now shows that the transport is apparently necessary for NGF to activate CREB, a protein that regulates genes that respond to NGF.

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THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Obstructed Axonal Transport of BDNF and Its Receptor TrkB in Experimental Glaucoma.
M. E. Pease, S. J. McKinnon, H. A. Quigley, L. A. Kerrigan–Baumrind, and D. J. Zack (2000)
Invest. Ophthalmol. Vis. Sci. 41, 764-774
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