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Science 8 August 1997:
Vol. 277. no. 5327, p. 768
DOI: 10.1126/science.277.5327.768
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Research News

CANCER RESEARCH:
How TRAIL Kills Cancer Cells, But Not Normal Cells

Trisha Gura

Cancer cells are much more susceptible than normal cells to the cell-death-inducing effects of a protein known as TRAIL, a difference that may aid researchers who want to develop new cancer therapies. The reason for the difference has been unclear, but three groups, two of them writing on pages 815 and 818 of this issue, have now solved the puzzle: Normal cells, but apparently not cancer cells, produce a "decoy receptor" that binds TRAIL, but is incapable of transmitting its death message to the cell interior.

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THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Activated Protein C Decreases Tumor Necrosis Factor Related Apoptosis-Inducing Ligand by an EPCR- Independent Mechanism Involving Egr-1/Erk-1/2 Activation.
L. A. O'Brien, M. A. Richardson, S. F. Mehrbod, D. T. Berg, B. Gerlitz, A. Gupta, and B. W. Grinnell (2007)
Arterioscler Thromb Vasc Biol 27, 2634-2641
   Abstract »    Full Text »    PDF »
Quercetin enhances TRAIL-mediated apoptosis in colon cancer cells by inducing the accumulation of death receptors in lipid rafts.
F. H. Psahoulia, K. G. Drosopoulos, L. Doubravska, L. Andera, and A. Pintzas (2007)
Mol. Cancer Ther. 6, 2591-2599
   Abstract »    Full Text »    PDF »
Differential Inhibition of TRAIL-Mediated DR5-DISC Formation by Decoy Receptors 1 and 2..
D. Merino, N. Lalaoui, A. Morizot, P. Schneider, E. Solary, and O. Micheau (2006)
Mol. Cell. Biol. 26, 7046-7055
   Abstract »    Full Text »    PDF »
Lymphoma cell apoptosis in the liver induced by distant murine cytomegalovirus infection..
K. C. Erlach, V. Bohm, C. K. Seckert, M. J. Reddehase, and J. Podlech (2006)
J. Virol. 80, 4801-4819
   Abstract »    Full Text »    PDF »
CD4+ T-cell death induced by infectious and noninfectious HIV-1: role of type 1 interferon-dependent, TRAIL/DR5-mediated apoptosis.
J.-P. Herbeuval, J.-C. Grivel, A. Boasso, A. W. Hardy, C. Chougnet, M. J. Dolan, H. Yagita, J. D. Lifson, and G. M. Shearer (2005)
Blood 106, 3524-3531
   Abstract »    Full Text »    PDF »
Role of Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand in Immune Response to Influenza Virus Infection in Mice.
E. Ishikawa, M. Nakazawa, M. Yoshinari, and M. Minami (2005)
J. Virol. 79, 7658-7663
   Abstract »    Full Text »    PDF »
TNF-related apoptosis-inducing ligand (TRAIL) in HIV-1-infected patients and its in vitro production by antigen-presenting cells.
J.-P. Herbeuval, A. Boasso, J.-C. Grivel, A. W. Hardy, S. A. Anderson, M. J. Dolan, C. Chougnet, J. D. Lifson, and G. M. Shearer (2005)
Blood 105, 2458-2464
   Abstract »    Full Text »    PDF »
TRAIL and KILLER Are Expressed and Induce Apoptosis in the Murine Preimplantation Embryo.
J. K. Riley, J. M. Heeley, A. H. Wyman, E. L. Schlichting, and K. H. Moley (2004)
Biol Reprod 71, 871-877
   Abstract »    Full Text »    PDF »
Translational Control of Tumor Necrosis Factor-related Apoptosis-inducing Ligand Death Receptor Expression in Melanoma Cells.
X. Y. Zhang, X. D. Zhang, J. M. Borrow, T. Nguyen, and P. Hersey (2004)
J. Biol. Chem. 279, 10606-10614
   Abstract »    Full Text »    PDF »
Interleukin-1{beta} and Tumor Necrosis Factor (TNF)-{alpha} Sensitize Human Thyroid Epithelial Cells to TNF-Related Apoptosis-Inducing Ligand-Induced Apoptosis through Increases in Procaspase-7 and Bid, and the Down-Regulation of p44/42 Mitogen-Activated Protein Kinase Activity.
E. Mezosi, S. H. Wang, S. Utsugi, L. Bajnok, J. D. Bretz, P. G. Gauger, N. W. Thompson, and J. R. Baker Jr. (2004)
J. Clin. Endocrinol. Metab. 89, 250-257
   Abstract »    Full Text »    PDF »
Synergistic Interactions of Chemotherapeutic Drugs and Tumor Necrosis Factor-related Apoptosis-inducing Ligand/Apo-2 Ligand on Apoptosis and on Regression of Breast Carcinoma in Vivo.
T. R. Singh, S. Shankar, X. Chen, M. Asim, and R. K. Srivastava (2003)
Cancer Res. 63, 5390-5400
   Abstract »    Full Text »    PDF »
Role of Antiapoptotic Proteins in Tumor Necrosis Factor-related Apoptosis-inducing Ligand and Cisplatin-augmented Apoptosis.
J. H. Kim, M. Ajaz, A. Lokshin, and Y. J. Lee (2003)
Clin. Cancer Res. 9, 3134-3141
   Abstract »    Full Text »    PDF »
MEK/ERK pathway is aberrantly active in Hodgkin disease: a signaling pathway shared by CD30, CD40, and RANK that regulates cell proliferation and survival.
B. Zheng, P. Fiumara, Y. V. Li, G. Georgakis, V. Snell, M. Younes, J. N. Vauthey, A. Carbone, and A. Younes (2003)
Blood 102, 1019-1027
   Abstract »    Full Text »    PDF »
Macrophages From Cancer Patients: Analysis of TRAIL, TRAIL Receptors, and Colon Tumor Cell Apoptosis.
J.-P. Herbeuval, C. Lambert, O. Sabido, M. Cottier, P. Fournel, M. Dy, and C. Genin (2003)
J Natl Cancer Inst 95, 611-621
   Abstract »    Full Text »    PDF »
Differential Roles of RelA (p65) and c-Rel Subunits of Nuclear Factor {kappa}B in Tumor Necrosis Factor-related Apoptosis-inducing Ligand Signaling.
X. Chen, K. Kandasamy, and R. K. Srivastava (2003)
Cancer Res. 63, 1059-1066
   Abstract »    Full Text »    PDF »
TRAIL-induced apoptosis of authentic myeloma cells does not correlate with the procaspase-8/cFLIP ratio.
A. Spencer, S.-L. Yeh, K. Koutrevelis, C. Baulch-Brown ;, N. Mitsiades, C. Mitsiades, K. C. Anderson, and S. P. Treon (2002)
Blood 100, 3049-3050
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Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand Induces Caspase-Dependent Interleukin-8 Expression and Apoptosis in Human Astroglioma Cells.
C. Choi, O. Kutsch, J. Park, T. Zhou, D.-W. Seol, and E. N. Benveniste (2002)
Mol. Cell. Biol. 22, 724-736
   Abstract »    Full Text »    PDF »
Pro-survival Function of Akt/Protein Kinase B in Prostate Cancer Cells. RELATIONSHIP WITH TRAIL RESISTANCE.
H. Thakkar, X. Chen, F. Tyan, S. Gim, H. Robinson, C. Lee, S. K. Pandey, C. Nwokorie, N. Onwudiwe, and R. K. Srivastava (2001)
J. Biol. Chem. 276, 38361-38369
   Abstract »    Full Text »    PDF »
Disruption of NF-{kappa}B Signaling Reveals a Novel Role for NF-{kappa}B in the Regulation of TNF-Related Apoptosis-Inducing Ligand Expression.
T. M. Baetu, H. Kwon, S. Sharma, N. Grandvaux, and J. Hiscott (2001)
J. Immunol. 167, 3164-3173
   Abstract »    Full Text »    PDF »
Down-Regulation of the erbB-2 Receptor by Trastuzumab (Herceptin) Enhances Tumor Necrosis Factor-related Apoptosis-inducing Ligand-mediated Apoptosis in Breast and Ovarian Cancer Cell Lines that Overexpress erbB-2.
M. Cuello, S. A. Ettenberg, A. S. Clark, M. M. Keane, R. H. Posner, M. M. Nau, P. A. Dennis, and S. Lipkowitz (2001)
Cancer Res. 61, 4892-4900
   Abstract »    Full Text »    PDF »
Mechanisms of Apoptosis.
J. C. Reed (2000)
Am. J. Pathol. 157, 1415-1430
   Abstract »    Full Text »    PDF »
TNF-related apoptosis-inducing ligand (TRAIL) as a negative regulator of normal human erythropoiesis.
L. Zamai, P. Secchiero, S. Pierpaoli, A. Bassini, S. Papa, E. S. Alnemri, L. Guidotti, M. Vitale, and G. Zauli (2000)
Blood 95, 3716-3724
   Abstract »    Full Text »    PDF »
Increased Expression of Death Receptors 4 and 5 Synergizes the Apoptosis Response to Combined Treatment with Etoposide and TRAIL.
S. B. Gibson, R. Oyer, A. C. Spalding, S. M. Anderson, and G. L. Johnson (2000)
Mol. Cell. Biol. 20, 205-212
   Abstract »    Full Text »    PDF »
TRAIL Death Pathway Expression and Induction in Thyroid Follicular Cells.
J. D. Bretz, M. Rymaszewski, P. L. Arscott, A. Myc, K. B. Ain, N. W. Thompson, and J. R. Baker Jr. (1999)
J. Biol. Chem. 274, 23627-23632
   Abstract »    Full Text »    PDF »
IFN-{gamma} Mediates a Novel Antiviral Activity Through Dynamic Modulation of TRAIL and TRAIL Receptor Expression.
L. M. Sedger, D. M. Shows, R. A. Blanton, J. J. Peschon, R. G. Goodwin, D. Cosman, and S. R. Wiley (1999)
J. Immunol. 163, 920-926
   Abstract »    Full Text »    PDF »
Chemotherapy Augments TRAIL-induced Apoptosis in Breast Cell Lines.
M. M. Keane, S. A. Ettenberg, M. M. Nau, E. K. Russell, and S. Lipkowitz (1999)
Cancer Res. 59, 734-741
   Abstract »    Full Text »    PDF »
Natural Killer (NK) Cell-mediated Cytotoxicity: Differential Use of TRAIL and Fas Ligand by Immature and Mature Primary Human NK Cells.
L. Zamai, M. Ahmad, I. M. Bennett, L. Azzoni, E. S. Alnemri, and B. Perussia (1998)
J. Exp. Med. 188, 2375-2380
   Abstract »    Full Text »    PDF »


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