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Science 18 July 1997:
Vol. 277. no. 5324, p. 319
DOI: 10.1126/science.277.5324.319

Research News

BIOCHEMISTRY:
Hijacking a Cell's Chemical Paths to Make New Antibiotics

Robert F. Service

Many antibiotics have a complex molecular architecture that makes them extremely difficult to synthesize, making it hard to create new ones to combat resistant bacteria. On page 367, however, a group of biochemists describes a way to hijack the antibiotic-producing chemical pathways of bacteria, exploiting them to produce a wide variety of new compounds.

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THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Family 6 Carbohydrate Binding Modules in beta-Agarases Display Exquisite Selectivity for the Non-reducing Termini of Agarose Chains.
J. Henshaw, A. Horne-Bitschy, A. L. van Bueren, V. A. Money, D. N. Bolam, M. Czjzek, N. A. Ekborg, R. M. Weiner, S. W. Hutcheson, G. J. Davies, et al. (2006)
J. Biol. Chem. 281, 17099-17107
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