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Science 11 July 1997:
Vol. 277. no. 5323, p. 182
DOI: 10.1126/science.277.5323.182

Research News

DEVELOPMENTAL BIOLOGY:
One Molecule Orchestrates Amoebae

Trisha Gura

Biologists have struggled for years to understand the signals that coordinate the amoebalike cells of Dictyostelium. When food is scarce, these cells band together to form a mound that crawls to better pastures, then disperse by building a stalk and a spore body. On page 251, researchers show that a single molecule—an enzyme called PKA—can single-handedly drive all steps of development.

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Science. ISSN 0036-8075 (print), 1095-9203 (online)