Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 11 July 1997:
Vol. 277. no. 5323, pp. 180 - 181
DOI: 10.1126/science.277.5323.180
Prev | Table of Contents | Next

Research News

GENETICS:
Newfound Gene Holds Key to Cell's Cholesterol Traffic

Elizabeth Pennisi

On page 228, researchers report that they have tracked down the gene that is mutated in a rare genetic disorder called Niemann-Pick type C disease, in which cells cannot process cholesterol and become glutted with the fatlike molecule. The protein product of the gene seems to sense a cell's level of cholesterol and help shuttle it from one part of the cell to another. An identical gene is at fault in a mouse model of the disease, as another group reports on page 232, which should make it easier to test ideas about the protein's function.

Read the Full Text


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
A Mutation in Af4 Is Predicted to Cause Cerebellar Ataxia and Cataracts in the Robotic Mouse.
A. M. Isaacs, P. L. Oliver, E. L. Jones, A. Jeans, A. Potter, B. H. Hovik, P. M. Nolan, L. Vizor, P. Glenister, A. K. Simon, et al. (2003)
J. Neurosci. 23, 1631-1637
   Abstract »    Full Text »    PDF »
GENE DEFECT IN NIEMANN-PICK DISEASE IDENTIFIED.
(1997)
Journal Watch (General) 1997, 5
   Full Text »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)