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Science 6 June 1997:
Vol. 276. no. 5318, p. 1502
DOI: 10.1126/science.276.5318.1502
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Research News

GENETICS:
No Bones About a Genetic Switch for Bone Growth

Steven Dickman

Researchers have identified what may be a master gene for bone growth. Evidence from human families, knockout mice, and cell culture shows that the gene turns precursor cells into osteoblasts, the cells that secrete bony matrix, and switches on at least one bone protein and probably many more. When mutated, it also causes a disease known as cleidocranial dysplasia, marked by skeletal abnormalities including a missing collarbone, soft spots in the skull, and stunted growth.

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THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Mucins and Molluscan Calcification. MOLECULAR CHARACTERIZATION OF MUCOPERLIN, A NOVEL MUCIN-LIKE PROTEIN FROM THE NACREOUS SHELL LAYER OF THE FAN MUSSEL PINNA NOBILIS (BIVALVIA, PTERIOMORPHIA).
F. Marin, P. Corstjens, B. de Gaulejac, E. de Vrind-De Jong, and P. Westbroek (2000)
J. Biol. Chem. 275, 20667-20675
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Science. ISSN 0036-8075 (print), 1095-9203 (online)