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Science 6 June 1997:
Vol. 276. no. 5318, pp. 1495 - 1497
DOI: 10.1126/science.276.5318.1495

Research News

CELL BIOLOGY:
How the Nucleus Gets It Together

Elizabeth Pennisi

At one time, cell biologists thought that the various reactions needed to make and then finish a messenger RNA--all of which are necessary if protein synthesis is to take place--could occur anywhere in the nucleus. But recent cytological and biochemical studies are revealing that the reactions are highly coordinated in space and time. Indeed, the synthetic and finishing reactions may be coupled with the aid of the synthesizing enzyme itself.

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THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Three-dimensional Visualization of Transcription Sites and Their Association with Splicing Factor–rich Nuclear Speckles.
X. Wei, S. Somanathan, J. Samarabandu, and R. Berezney (1999)
J. Cell Biol. 146, 543-558
   Abstract »    Full Text »    PDF »
Brain Corticosteroid Receptor Balance in Health and Disease.
E. R. de Kloet, E. Vreugdenhil, M. S. Oitzl, and M. Joëls (1998)
Endocr. Rev. 19, 269-301
   Abstract »    Full Text »



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Science. ISSN 0036-8075 (print), 1095-9203 (online)