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Science 23 May 1997:
Vol. 276. no. 5316, pp. 1192 - 1193
DOI: 10.1126/science.276.5316.1192
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Research News

Biotechnology:
Antisense Aims for a Renaissance

Wade Roush

CAMBRIDGE, MASSACHUSETTS--Once plagued by side effects and mysterious failures, antisense technologies are now shedding their troubled image. Basic research has uncovered explanations--and solutions--to some of the earlier problems, and antisense drugs have shown promise in early clinical trials against cancer and Crohn's disease.

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THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Phase I Trial of ISIS 5132, an Antisense Oligonucleotide Inhibitor of c-raf-1, Administered by 24-hour Weekly Infusion to Patients with Advanced Cancer.
C. M. Rudin, J. Holmlund, G. F. Fleming, S. Mani, W. M. Stadler, P. Schumm, B. P. Monia, J. F. Johnston, R. Geary, R. Z. Yu, et al. (2001)
Clin. Cancer Res. 7, 1214-1220
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Potent Growth Inhibition of Leukemic Cells by Novel Ribbon-type Antisense Oligonucleotides to c-myb1.
I.-J. Moon, K. Choi, Y.-K. Choi, J.-E. Kim, Y. Lee, A. D. Schreiber, and J.-G. Park (2000)
J. Biol. Chem. 275, 4647-4653
   Abstract »    Full Text »    PDF »
Identification, purification and partial characterisation of an oligonucleotide receptor in membranes of HepG2 cells.
P. d. Diesbach, C. Berens, F. N'Kuli, M. Monsigny, E. Sonveaux, R. Wattiez, and P. J. Courtoy (2000)
Nucleic Acids Res. 28, 868-874
   Abstract »    Full Text »    PDF »
The Jun Kinase 2 Isoform Is Preferentially Required for Epidermal Growth Factor-Induced Transformation of Human A549 Lung Carcinoma Cells.
F. Bost, R. McKay, M. Bost, O. Potapova, N. M. Dean, and D. Mercola (1999)
Mol. Cell. Biol. 19, 1938-1949
   Abstract »    Full Text »    PDF »
Expression of Antisense to Integrin Subunit beta 3 Inhibits Microvascular Endothelial Cell Capillary Tube Formation in Fibrin.
S. M. Dallabrida, M. A. De Sousa, and D. H. Farrell (2000)
J. Biol. Chem. 275, 32281-32288
   Abstract »    Full Text »    PDF »


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