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Science 18 April 1997:
Vol. 276. no. 5311, pp. 374 - 375
DOI: 10.1126/science.276.5311.374
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Perspectives

Also see the archival list of Enhanced Perspectives

(Immunology) Enhanced: Antigen Presentation by Memory B Cells--The Sting Is in the Tail

David Tarlinton

Antibody molecules come in many forms. Some reside on the surfaces of immune cells, where they have a dual function. They transduce signals into the cell but also bind antigen so that it can be endocytosed and processed. In his Perspective, Tarlinton explains how three reports in this issue (Weiser et al. , Kaisho et al., and Achatz et al.) and one in EMBO Journal shed new light on how these surface-localized molecules can perform both of these functions--the key is in the intracellular tail.

The author is at The Walter and Eliza Hall Institute of Medical Research, Post Office Royal Melbourne Hospital, Victoria 3050, Australia. E-mail: tarlinton{at}wehi.edu.au

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THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
HS1-Associated Protein X-1 Interacts with Membrane-Bound IgE: Impact on Receptor-Mediated Internalization.
I. Oberndorfer, D. Schmid, R. Geisberger, G. Achatz-Straussberger, R. Crameri, M. Lamers, and G. Achatz (2006)
J. Immunol. 177, 1139-1145
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