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Science 4 April 1997:
Vol. 276. no. 5309, pp. 38 - 39
DOI: 10.1126/science.276.5309.38
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Research News

Wade Roush

Researchers at Case Western Reserve University and Athersys Inc., both in Cleveland, report constructing the first wholly synthetic, self-replicating, human "microchromosomes," which are one-fifth to one-tenth the size of normal human chromosomes. Although the team hasn't yet found an efficient way of transplanting microchromosomes' self-assembling components into new cells--a crucial step before researchers can exploit them fully--human artificial chromosomes could eventually be used to study chromosomal functions and to ferry "repair genes" into target cells in gene therapy.

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THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Cationic liposome-DNA complexes: from liquid crystal science to gene delivery applications.
C. R Safinya, K. Ewert, A. Ahmad, H. M Evans, U. Raviv, D. J Needleman, A. J Lin, N. L Slack, C. George, and C. E Samuel (2006)
Phil Trans R Soc A 364, 2573-2596
   Abstract »    Full Text »    PDF »
An Inverted Hexagonal Phase of Cationic Liposome-DNA Complexes Related to DNA Release and Delivery.
I. Koltover, T. Salditt, J. O. Rädler, and C. R. Safinya (1998)
Science 281, 78-81
   Abstract »    Full Text »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)