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Science 28 March 1997:
Vol. 275. no. 5308, pp. 1876 - 1878
DOI: 10.1126/science.275.5308.1876
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Research News

Elizabeth Pennisi

Two teams, one of which reports its results on page 1943 and the other in the April issue of Nature Genetics, have ended in a near dead heat in their race to find what appears to be a particularly important tumor suppressor. The gene, located on chromosome 10, may be involved in several kinds of cancers, including gliomas, a deadly brain cancer, and prostate, breast, and kidney cancer. It encodes a protein, the amino acid sequence of which indicates that it is a tyrosine phosphatase, an enzyme that removes phosphate groups from the amino acid tyrosine. Cancer researchers had long suspected that such phosphatases might be tumor suppressors because they directly counteract the actions of another set of enzymes that play a key role in cell's growth-stimulating pathways. This is the first direct proof of that suspicion.

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THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Progress in the pathogenesis and genetics of Parkinson's disease.
Y. Mizuno, N. Hattori, S.-i. Kubo, S. Sato, K. Nishioka, T. Hatano, H. Tomiyama, M. Funayama, Y. Machida, and H. Mochizuki (2008)
Phil Trans R Soc B 363, 2215-2227
   Abstract »    Full Text »    PDF »
Identification of Multiple Phosphoinositide-specific Phospholipases D as New Regulatory Enzymes for Phosphatidylinositol 3,4,5-Trisphosphate.
T.-T. Ching, D.-S. Wang, A.-L. Hsu, P.-J. Lu, and C.-S. Chen (1999)
J. Biol. Chem. 274, 8611-8617
   Abstract »    Full Text »    PDF »
Aneuploidy correlated 100% with chemical transformation of Chinese hamster cells.
R. Li, G. Yerganian, P. Duesberg, A. Kraemer, A. Willer, C. Rausch, and R. Hehlmann (1997)
PNAS 94, 14506-14511
   Abstract »    Full Text »    PDF »


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