Science 31 January 1997: Vol. 275. no. 5300, pp. 630 - 631 DOI: 10.1126/science.275.5300.630

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The A{beta}Cs of A{beta}-cleaving Proteases.

M. A. Leissring (2008)
J. Biol. Chem. 283, 29645-29649
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Relation between smoking and risk of dementia and Alzheimer disease: The Rotterdam Study.

C. Reitz, T. den Heijer, C. van Duijn, A. Hofman, and M.M.B. Breteler (2007)
Neurology 69, 998-1005
 |  Abstract »  |  Full Text »  |  PDF »

p53-dependent Aph-1 and Pen-2 Anti-apoptotic Phenotype Requires the Integrity of the {gamma}-Secretase Complex but Is Independent of Its Activity.

J. Dunys, T. Kawarai, J. Sevalle, V. Dolcini, P. St. George-Hyslop, C. A. Da Costa, and F. Checler (2007)
J. Biol. Chem. 282, 10516-10525
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Transcriptional Regulation of PEN-2, a Key Component of the {gamma}-Secretase Complex, by CREB.

R. Wang, Y.-w. Zhang, P. Sun, R. Liu, X. Zhang, X. Zhang, K. Xia, J. Xia, H. Xu, and Z. Zhang (2006)
Mol. Cell. Biol. 26, 1347-1354
 |  Abstract »  |  Full Text »  |  PDF »

Presenilin 1 Deficiency Alters the Activity of Voltage-Gated Ca2+ Channels in Cultured Cortical Neurons.

D. G. Cook, X. Li, S. D. Cherry, and A. R. Cantrell (2005)
J Neurophysiol 94, 4421-4429
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Translational Research on the Way to Effective Therapy for Alzheimer Disease.

R. N. Rosenberg (2005)
Arch Gen Psychiatry 62, 1186-1192
 |  Abstract »  |  Full Text »  |  PDF »

Effect of smoking and time on cognitive function in the elderly without dementia.

C. Reitz, J. Luchsinger, M.-X. Tang, and R. Mayeux (2005)
Neurology 65, 870-875
 |  Abstract »  |  Full Text »  |  PDF »

Aggregation of vascular risk factors and risk of incident Alzheimer disease.

J. A. Luchsinger, C. Reitz, L. S. Honig, M. X. Tang, S. Shea, and R. Mayeux (2005)
Neurology 65, 545-551
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Decay bounds in a model for aggregation of microglia: application to Alzheimer's disease senile plaques.

R.A Quinlan and B Straughan (2005)
Proc R Soc A 461, 2887-2897
 |  Abstract »  |  Full Text »  |  PDF »

GM1 Ganglioside and the Seeding of Amyloid in Alzheimer's Disease: Endogenous Seed for Alzheimer Amyloid.

K. Yanagisawa (2005)
Neuroscientist 11, 250-260
 |  Abstract »  |  PDF »

Metal Ion-dependent Effects of Clioquinol on the Fibril Growth of an Amyloid {beta} Peptide.

B. Raman, T. Ban, K.-i. Yamaguchi, M. Sakai, T. Kawai, H. Naiki, and Y. Goto (2005)
J. Biol. Chem. 280, 16157-16162
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Macrophage Inflammatory Protein 2 Inhibits {beta}-Amyloid Peptide (1-42)-Mediated Hippocampal Neuronal Apoptosis through Activation of Mitogen-Activated Protein Kinase and Phosphatidylinositol 3-Kinase Signaling Pathways.

K. Watson and G.-H. Fan (2005)
Mol. Pharmacol. 67, 757-765
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Curcumin Inhibits Formation of Amyloid {beta} Oligomers and Fibrils, Binds Plaques, and Reduces Amyloid in Vivo.

F. Yang, G. P. Lim, A. N. Begum, O. J. Ubeda, M. R. Simmons, S. S. Ambegaokar, P. P. Chen, R. Kayed, C. G. Glabe, S. A. Frautschy, et al. (2005)
J. Biol. Chem. 280, 5892-5901
 |  Abstract »  |  Full Text »  |  PDF »

Prevention of Alzheimer's Disease-associated A{beta} Aggregation by Rationally Designed Nonpeptidic {beta}-Sheet Ligands.

P. Rzepecki, L. Nagel-Steger, S. Feuerstein, U. Linne, O. Molt, R. Zadmard, K. Aschermann, M. Wehner, T. Schrader, and D. Riesner (2004)
J. Biol. Chem. 279, 47497-47505
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Presenilins and {gamma}-Secretase Inhibitors Affect Intracellular Trafficking and Cell Surface Localization of the {gamma}-Secretase Complex Components.

H. Wang, W.-j. Luo, Y.-w. Zhang, Y.-M. Li, G. Thinakaran, P. Greengard, and H. Xu (2004)
J. Biol. Chem. 279, 40560-40566
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Common Mechanism of Ligand Recognition by Group II/III WW Domains: REDEFINING THEIR FUNCTIONAL CLASSIFICATION.

Y. Kato, K. Nagata, M. Takahashi, L. Lian, J. J. Herrero, M. Sudol, and M. Tanokura (2004)
J. Biol. Chem. 279, 31833-31841
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A Seed for Alzheimer Amyloid in the Brain.

H. Hayashi, N. Kimura, H. Yamaguchi, K. Hasegawa, T. Yokoseki, M. Shibata, N. Yamamoto, M. Michikawa, Y. Yoshikawa, K. Terao, et al. (2004)
J. Neurosci. 24, 4894-4902
 |  Abstract »  |  Full Text »  |  PDF »

Search Strategies Used by APP Transgenic Mice During Navigation in the Morris Water Maze.

C. Janus (2004)
Learn. Mem. 11, 337-346
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Copper Binding to the Amyloid-{beta} (A{beta}) Peptide Associated with Alzheimer's Disease: FOLDING, COORDINATION GEOMETRY, pH DEPENDENCE, STOICHIOMETRY, AND AFFINITY OF A{beta}-(1-28): INSIGHTS FROM A RANGE OF COMPLEMENTARY SPECTROSCOPIC TECHNIQUES.

C. D. Syme, R. C. Nadal, S. E. J. Rigby, and J. H. Viles (2004)
J. Biol. Chem. 279, 18169-18177
 |  Abstract »  |  Full Text »  |  PDF »

Metabolite-initiated protein misfolding may trigger Alzheimer's disease.

Q. Zhang, E. T. Powers, J. Nieva, M. E. Huff, M. A. Dendle, J. Bieschke, C. G. Glabe, A. Eschenmoser, P. Wentworth Jr., R. A. Lerner, et al. (2004)
PNAS 101, 4752-4757
 |  Abstract »  |  Full Text »  |  PDF »

The Human Amyloid-{beta} Precursor Protein770 Mutation V717F Generates Peptides Longer Than Amyloid-{beta}-(40-42) and Flocculent Amyloid Aggregates.

A. E. Roher, T. A. Kokjohn, C. Esh, N. Weiss, J. Childress, W. Kalback, D. C. Luehrs, J. Lopez, D. Brune, Y.-M. Kuo, et al. (2004)
J. Biol. Chem. 279, 5829-5836
 |  Abstract »  |  Full Text »  |  PDF »

AATF Inhibits Aberrant Production of Amyloid {beta} Peptide 1-42 by Interacting Directly with Par-4.

Q. Guo and J. Xie (2004)
J. Biol. Chem. 279, 4596-4603
 |  Abstract »  |  Full Text »  |  PDF »

Dehydroepiandrosterone: Is There a Role for Replacement?.

K. K. Dhatariya and K. S. Nair (2003)
Mayo Clin. Proc. 78, 1257-1273
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Amyloid-{beta} Immunization Effectively Reduces Amyloid Deposition in FcR{gamma}-/- Knock-Out Mice.

P. Das, V. Howard, N. Loosbrock, D. Dickson, M. P. Murphy, and T. E. Golde (2003)
J. Neurosci. 23, 8532-8538
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A{beta}25-35-Induced Depression of Long-Term Potentiation in Area CA1 In Vivo and In Vitro Is Attenuated by Verapamil.

D. B. Freir, D. A. Costello, and C. E. Herron (2003)
J Neurophysiol 89, 3061-3069
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Neuroimaging and Early Diagnosis of Alzheimer Disease: A Look to the Future.

J. R. Petrella, R. E. Coleman, and P. M. Doraiswamy (2003)
Radiology 226, 315-336
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Prevention of Transthyretin Amyloid Disease by Changing Protein Misfolding Energetics.

P. Hammarstrom, R. L. Wiseman, E. T. Powers, and J. W. Kelly (2003)
Science 299, 713-716
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New Class of Inhibitors of Amyloid-beta Fibril Formation. IMPLICATIONS FOR THE MECHANISM OF PATHOGENESIS IN ALZHEIMER'S DISEASE.

H. A. Lashuel, D. M. Hartley, D. Balakhaneh, A. Aggarwal, S. Teichberg, and D. J. E. Callaway (2002)
J. Biol. Chem. 277, 42881-42890
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Overexpression of hAPPswe Impairs Rewarded Alternation and Contextual Fear Conditioning in a Transgenic Mouse Model of Alzheimer's Disease.

K. A. Corcoran, Y. Lu, R. S. Turner, and S. Maren (2002)
Learn. Mem. 9, 243-252
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Explaining the Cause of the Amyloid Burden in Alzheimer Disease.

R. N. Rosenberg (2002)
Arch Neurol 59, 1367-1368
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Caloric Intake and the Risk of Alzheimer Disease.

J. A. Luchsinger, M.-X. Tang, S. Shea, and R. Mayeux (2002)
Arch Neurol 59, 1258-1263
 |  Abstract »  |  Full Text »  |  PDF »

Presenile dementia syndromes: an update on taxonomy and diagnosis.

M D Greicius, M D Geschwind, and B L Miller (2002)
J. Neurol. Neurosurg. Psychiatry 72, 691-700
 |  Abstract »  |  Full Text »  |  PDF »

Cholinergic Changes in the APP23 Transgenic Mouse Model of Cerebral Amyloidosis.

S. Boncristiano, M. E. Calhoun, P. H. Kelly, M. Pfeifer, L. Bondolfi, M. Stalder, A. L. Phinney, D. Abramowski, C. Sturchler-Pierrat, A. Enz, et al. (2002)
J. Neurosci. 22, 3234-3243
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Use of cholinesterase inhibitors in dementia.

M. Holden and C. Kelly (2002)
Advan. Psychiatr. Treat. 8, 89-96
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Conformational Abs recognizing a generic amyloid fibril epitope.

B. O'Nuallain and R. Wetzel (2002)
PNAS
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Membrane-bound alpha -Synuclein Has a High Aggregation Propensity and the Ability to Seed the Aggregation of the Cytosolic Form.

H.-J. Lee, C. Choi, and S.-J. Lee (2002)
J. Biol. Chem. 277, 671-678
 |  Abstract »  |  Full Text »

Alzheimer's disease and other dementias: A review.

S. Rogan and C. F. Lippa (2002)
American Journal of Alzheimer's Disease and Other Dementias 17, 11-17
 |  Abstract »  |  PDF »

The V122I cardiomyopathy variant of transthyretin increases the velocity of rate-limiting tetramer dissociation, resulting in accelerated amyloidosis.

X. Jiang, J. N. Buxbaum, and J. W. Kelly (2001)
PNAS 98, 14943-14948
 |  Abstract »  |  Full Text »  |  PDF »

Regulation of Preprotachykinin-A Gene Expression in an Animal Model of Alzheimer's Disease.

P. Pompei, R. Severini, D. Pediconi, M. Angeletti, A. Eleuteri, P. Fattoretti, C. Bertoni-Freddari, and E. Fioretti (2001)
J. Histochem. Cytochem. 49, 1469-1470
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Support for the multigenic hypothesis of amyloidosis: The binding stoichiometry of retinol-binding protein, vitamin A, and thyroid hormone influences transthyretin amyloidogenicity invitro.

J. T. White and J. W. Kelly (2001)
PNAS
 |  Abstract »  |  Full Text »  |  PDF »

Generation of Aggregated {beta}-Amyloid in the Rat Hippocampus Impairs Synaptic Transmission and Plasticity and Causes Memory Deficits.

A. Stephan, S. Laroche, and S. Davis (2001)
J. Neurosci. 21, 5703-5714
 |  Abstract »  |  Full Text »  |  PDF »

Peripheral anti-Abeta antibody alters CNS and plasma Abeta clearance and decreases brain Abeta burden in a mouse model of Alzheimer's disease.

R. B. DeMattos, K. R. Bales, D. J. Cummins, J.-C. Dodart, S. M. Paul, and D. M. Holtzman (2001)
PNAS
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Phenserine regulates translation of beta -amyloid precursor protein mRNA by a putative interleukin-1 responsive element, a target for drug development.

K. T. Y. Shaw, T. Utsuki, J. Rogers, Q.-S. Yu, K. Sambamurti, A. Brossi, Y.-W. Ge, D. K. Lahiri, and N. H. Greig (2001)
PNAS
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Alzheimer's Disease: Genes, Proteins, and Therapy.

D. J. Selkoe (2001)
Physiol Rev 81, 741-766
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Characterization of Recombinant, Soluble {beta}-Secretase from an Insect Cell Expression System.

W. D. Mallender, D. Yager, L. Onstead, M. R. Nichols, C. Eckman, K. Sambamurti, L. M. Kopcho, J. Marcinkeviciene, R. A. Copeland, and T. L. Rosenberry (2001)
Mol. Pharmacol. 59, 619-626
 |  Abstract »  |  Full Text »

Destabilization of Ca2+-free gelsolin may not be responsible for proteolysis in Familial Amyloidosis of Finnish Type.

G. Ratnaswamy, M. E. Huff, A. I. Su, S. Rion, and J. W. Kelly (2001)
PNAS
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Abeta amyloid fibrils possess a core structure highly resistant to hydrogen exchange.

I. Kheterpal, S. Zhou, K. D. Cook, and R. Wetzel (2000)
PNAS
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Human bleomycin hydrolase regulates the secretion of amyloid precursor protein.

I. M. LEFTEROV, R. P. KOLDAMOVA, and J. S. LAZO (2000)
FASEB J 14, 1837-1847
 |  Abstract »  |  Full Text »

The molecular and genetic basis of AD: The end of the beginning: The 2000 Wartenberg lecture.

R. N. Rosenberg (2000)
Neurology 54, 2045-2054
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The Plasmin System Is Induced by and Degrades Amyloid-beta Aggregates.

H. M. Tucker, M. Kihiko, J. N. Caldwell, S. Wright, T. Kawarabayashi, D. Price, D. Walker, S. Scheff, J. P. McGillis, R. E. Rydel, et al. (2000)
J. Neurosci. 20, 3937-3946
 |  Abstract »  |  Full Text »  |  PDF »

D-beta -Hydroxybutyrate protects neurons in models of Alzheimer's and Parkinson's disease.

Y. Kashiwaya, T. Takeshima, N. Mori, K. Nakashima, K. Clarke, and R. L. Veech (2000)
PNAS 97, 5440-5444
 |  Abstract »  |  Full Text »  |  PDF »

Analysis of mammalian central nervous system gene expression and function using bacterial artificial chromosome-mediated transgenesis.

N. Heintz (2000)
Hum. Mol. Genet. 9, 937-943
 |  Abstract »  |  Full Text »  |  PDF »

Correlation Between Elevated Levels of Amyloid {beta}-Peptide in the Brain and Cognitive Decline.

J. Naslund, V. Haroutunian, R. Mohs, K. L. Davis, P. Davies, P. Greengard, and J. D. Buxbaum (2000)
JAMA 283, 1571-1577
 |  Abstract »  |  Full Text »  |  PDF »

Caspase-2 Mediates Neuronal Cell Death Induced by beta -Amyloid.

C. M. Troy, S. A. Rabacchi, W. J. Friedman, T. F. Frappier, K. Brown, and M. L. Shelanski (2000)
J. Neurosci. 20, 1386-1392
 |  Abstract »  |  Full Text »  |  PDF »

AMY plaques in familial AD: Comparison with sporadic Alzheimer's disease.

C. F. Lippa, M. L. Schmidt, L. E. Nee, T. Bird, D. Nochlin, C. Hulette, H. Mori, V. M.- Y. Lee, and J. Q. Trojanowski (2000)
Neurology 54, 100
 |  Abstract »  |  Full Text »  |  PDF »

Cultured inclusion-body myositis muscle fibers do not accumulate {beta}-amyloid precursor protein and can be innervated.

J. McFerrin, W. K. Engel, and V. Askanas (1999)
Neurology 53, 2184
 |  Abstract »  |  Full Text »  |  PDF »

Identification of a Novel PSD-95/Dlg/ZO-1 (PDZ)-like Protein Interacting with the C Terminus of Presenilin-1.

X. Xu, Y.-c. Shi, X. Wu, P. Gambetti, D. Sui, and M.-Z. Cui (1999)
J. Biol. Chem. 274, 32543-32546
 |  Abstract »  |  Full Text »  |  PDF »

Manipulating the Amyloid-beta Aggregation Pathway with Chemical Chaperones.

D.-S. Yang, C. M. Yip, T. H. J. Huang, A. Chakrabartty, and P. E. Fraser (1999)
J. Biol. Chem. 274, 32970-32974
 |  Abstract »  |  Full Text »  |  PDF »

Elimination of the Class A Scavenger Receptor Does Not Affect Amyloid Plaque Formation or Neurodegeneration in Transgenic Mice Expressing Human Amyloid Protein Precursors.

F. Huang, M. Buttini, T. Wyss-Coray, L. McConlogue, T. Kodama, R. E. Pitas, and L. Mucke (1999)
Am. J. Pathol. 155, 1741-1747
 |  Abstract »  |  Full Text »  |  PDF »

Presenilin 2 deficiency causes a mild pulmonary phenotype and no changes in amyloid precursor protein processing but enhances the embryonic lethal phenotype of presenilin 1 deficiency.

A. Herreman, D. Hartmann, W. Annaert, P. Saftig, K. Craessaerts, L. Serneels, L. Umans, V. Schrijvers, F. Checler, H. Vanderstichele, et al. (1999)
PNAS 96, 11872-11877
 |  Abstract »  |  Full Text »  |  PDF »

Presenilin 1 Suppresses the Function of c-Jun Homodimers via Interaction with QM/Jif-1.

I. Imafuku, T. Masaki, M. Waragai, S. Takeuchi, M. Kawabata, S.-i. Hirai, S. Ohno, L.E. Nee, C.F. Lippa, I. Kanazawa, et al. (1999)
J. Cell Biol. 147, 121-134
 |  Abstract »  |  Full Text »  |  PDF »

Amyloid beta -Protein Fibrillogenesis. STRUCTURE AND BIOLOGICAL ACTIVITY OF PROTOFIBRILLAR INTERMEDIATES.

D. M. Walsh, D. M. Hartley, Y. Kusumoto, Y. Fezoui, M. M. Condron, A. Lomakin, G. B. Benedek, D. J. Selkoe, and D. B. Teplow (1999)
J. Biol. Chem. 274, 25945-25952
 |  Abstract »  |  Full Text »  |  PDF »

Caspase-6 Role in Apoptosis of Human Neurons, Amyloidogenesis, and Alzheimer's Disease.

A. LeBlanc, H. Liu, C. Goodyer, C. Bergeron, and J. Hammond (1999)
J. Biol. Chem. 274, 23426-23436
 |  Abstract »  |  Full Text »  |  PDF »

Alzheimer Disease: Report of the Council on Scientific Affairs.

R. Guttman, R. D. Altman, N. H. Nielsen, and for the Council on Scientific Affairs, American Me (1999)
Arch Fam Med 8, 347-353
 |  Abstract »  |  Full Text »  |  PDF »

Distribution and Fluidizing Action of Soluble and Aggregated Amyloid beta -Peptide in Rat Synaptic Plasma Membranes.

R. P. Mason, R. F. Jacob, M. F. Walter, P. E. Mason, N. A. Avdulov, S. V. Chochina, U. Igbavboa, and W. G. Wood (1999)
J. Biol. Chem. 274, 18801-18807
 |  Abstract »  |  Full Text »  |  PDF »

Association of Microglia with Amyloid Plaques in Brains of APP23 Transgenic Mice.

M. Stalder, A. Phinney, A. Probst, B. Sommer, M. Staufenbiel, and M. Jucker (1999)
Am. J. Pathol. 154, 1673-1684
 |  Abstract »  |  Full Text »  |  PDF »

The biochemical pathway of neurofibrillary degeneration in aging and Alzheimer's disease.

A. Delacourte, J. P. David, N. Sergeant, L. Buee, A. Wattez, P. Vermersch, F. Ghozali, C. Fallet-Bianco, F. Pasquier, F. Lebert, et al. (1999)
Neurology 52, 1158
 |  Abstract »  |  Full Text »

Evolution of amyloid: What normal protein folding may tell us about fibrillogenesis and disease.

P. T. Lansbury Jr. (1999)
PNAS 96, 3342-3344
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In situ atomic force microscopy study of Alzheimer's beta -amyloid peptide on different substrates: New insights into mechanism of beta -sheet formation.

T. Kowalewski and D. M. Holtzman (1999)
PNAS 96, 3688-3693
 |  Abstract »  |  Full Text »  |  PDF »

Mapping the active site in vasoactive intestinal peptide to a core of four amino acids: Neuroprotective drug design.

I. Gozes, O. Perl, E. Giladi, A. Davidson, O. Ashur-Fabian, S. Rubinraut, and M. Fridkin (1999)
PNAS 96, 4143-4148
 |  Abstract »  |  Full Text »  |  PDF »

Competition of Aß amyloid peptide and apolipoprotein E for receptor-mediated endocytosis.

K. Winkler, H. Scharnagl, U. Tisljar, H. Hoschützky, I. Friedrich, M. M. Hoffmann, M. Hüttinger, H. Wieland, and W. März (1999)
J. Lipid Res. 40, 447-455
 |  Abstract »  |  Full Text »

A Novel Synthetic Oleanane Triterpenoid, 2-Cyano-3,12-dioxoolean-1,9-dien-28-oic Acid, with Potent Differentiating, Antiproliferative, and Anti-Inflammatory Activity.

N. Suh, Y. Wang, T. Honda, G. W. Gribble, E. Dmitrovsky, W. F. Hickey, R. A. Maue, A. E. Place, D. M. Porter, M. J. Spinella, et al. (1999)
Cancer Res. 59, 336-341
 |  Abstract »  |  Full Text »  |  PDF »

Insulin-degrading Enzyme Regulates Extracellular Levels of Amyloid beta -Protein by Degradation.

W. Q. Qiu, D. M. Walsh, Z. Ye, K. Vekrellis, J. Zhang, M. B. Podlisny, M. R. Rosner, A. Safavi, L. B. Hersh, and D. J. Selkoe (1998)
J. Biol. Chem. 273, 32730-32738
 |  Abstract »  |  Full Text »  |  PDF »

Increased F2-isoprostanes in Alzheimer's disease: evidence for enhanced lipid peroxidation in vivo.

D. Praticò, V. M.-Y.Lee, J. Q. Trojanowski, J. Rokach, and G. A. Fitzgerald (1998)
FASEB J 12, 1777-1783
 |  Abstract »  |  Full Text »

Molecular Chaperones: Biology and Prospects for Pharmacological Intervention.

D. F. Smith, L. Whitesell, and E. Katsanis (1998)
Pharmacol. Rev. 50, 493-514
 |  Abstract »  |  Full Text »  |  PDF »

Does Overexpression of ßAPP in Aging Muscle Have a Pathogenic Role and a Relevance to Alzheimer's Disease? : Clues from Inclusion Body Myositis, Cultured Human Muscle, and Transgenic Mice.

V. Askanas and W. K. Engel (1998)
Am. J. Pathol. 153, 1673-1677
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Amyloid-ß Deposition in Skeletal Muscle of Transgenic Mice : Possible Model of Inclusion Body Myopathy.

K.-i. Fukuchi, D. Pham, M. Hart, L. Li, and J. R. Lindsey (1998)
Am. J. Pathol. 153, 1687-1693
 |  Abstract »  |  Full Text »  |  PDF »

A Novel, Synergistic Interaction Between 17 beta -Estradiol and Glutathione in the Protection of Neurons against beta -Amyloid 25-35-Induced Toxicity In Vitro.

K. E. Gridley, P. S. Green, and J. W. Simpkins (1998)
Mol. Pharmacol. 54, 874-880
 |  Abstract »  |  Full Text »

Lewy Bodies Contain Altered {alpha}-Synuclein in Brains of Many Familial Alzheimer's Disease Patients with Mutations in Presenilin and Amyloid Precursor Protein Genes.

C. F. Lippa, H. Fujiwara, D. M.A. Mann, B. Giasson, M. Baba, M. L. Schmidt, L. E. Nee, B. O'Connell, D. A. Pollen, P. St. George-Hyslop, et al. (1998)
Am. J. Pathol. 153, 1365-1370
 |  Abstract »  |  Full Text »  |  PDF »

Inhibiting transthyretin conformational changes that lead to amyloid fibril formation.

S. A. Peterson, T. Klabunde, H. A. Lashuel, H. Purkey, J. C. Sacchettini, and J. W. Kelly (1998)
PNAS 95, 12956-12960
 |  Abstract »  |  Full Text »  |  PDF »

Protease Inhibitor Coinfusion with Amyloid beta -Protein Results in Enhanced Deposition and Toxicity in Rat Brain.

S. A. Frautschy, D. L. Horn, J. J. Sigel, M. E. Harris-White, J. J. Mendoza, F. Yang, T. C. Saido, and G. M. Cole (1998)
J. Neurosci. 18, 8311-8321
 |  Abstract »  |  Full Text »  |  PDF »

The Chaperone BiP/GRP78 Binds to Amyloid Precursor Protein and Decreases Abeta 40 and Abeta 42 Secretion.

Y. Yang, R. S. Turner, and J. R. Gaut (1998)
J. Biol. Chem. 273, 25552-25555
 |  Abstract »  |  Full Text »  |  PDF »

Regional Distribution of Neuritic Plaques in the Nondemented Elderly and Subjects With Very Mild Alzheimer Disease.

V. Haroutunian, D. P. Perl, D. P. Purohit, D. Marin, K. Khan, M. Lantz, K. L. Davis, and R. C. Mohs (1998)
Arch Neurol 55, 1185-1191
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Amyloid Precursor Protein Processing in Sterol Regulatory Element-binding Protein Site 2 Protease-deficient Chinese Hamster Ovary Cells.

S. L. Ross, F. Martin, L. Simonet, F. Jacobsen, R. Deshpande, R. Vassar, B. Bennett, Y. Luo, S. Wooden, S. Hu, et al. (1998)
J. Biol. Chem. 273, 15309-15312
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The X11alpha Protein Slows Cellular Amyloid Precursor Protein Processing and Reduces Abeta 40 and Abeta 42 Secretion.

J.-P. Borg, Y. Yang, M. De Taddeo-Borg, B. Margolis, and R. S. Turner (1998)
J. Biol. Chem. 273, 14761-14766
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Subcellular Distribution and Turnover of Presenilins in Transfected Cells.

J. Zhang, D. E. Kang, W. Xia, M. Okochi, H. Mori, D. J. Selkoe, and E. H. Koo (1998)
J. Biol. Chem. 273, 12436-12442
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Stable Complexes Involving Acetylcholinesterase and Amyloid-beta Peptide Change the Biochemical Properties of the Enzyme and Increase the Neurotoxicity of Alzheimer's Fibrils.

A. Alvarez, R. Alarcon, C. Opazo, E. O. Campos, F. J. Munoz, F. H. Calderon, F. Dajas, M. K. Gentry, B. P. Doctor, F. G. De Mello, et al. (1998)
J. Neurosci. 18, 3213-3223
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Protein Kinase C Activation Increases Release of Secreted Amyloid Precursor Protein without Decreasing Abeta Production in Human Primary Neuron Cultures..

A. C. LeBlanc, M. Koutroumanis, and C. G. Goodyer (1998)
J. Neurosci. 18, 2907-2913
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Fibrillar beta -Amyloid Induces Microglial Phagocytosis, Expression of Inducible Nitric Oxide Synthase, and Loss of a Select Population of Neurons in the Rat CNS In Vivo.

D. T. Weldon, S. D. Rogers, J. R. Ghilardi, M. P. Finke, J. P. Cleary, E. O'Hare, W. P. Esler, J. E. Maggio, and P. W. Mantyh (1998)
J. Neurosci. 18, 2161-2173
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Structural Transitions Associated with the Interaction of Alzheimer beta -Amyloid Peptides with Gangliosides.

J. McLaurin, T. Franklin, P. E. Fraser, and A. Chakrabartty (1998)
J. Biol. Chem. 273, 4506-4515
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The environmental dependency of protein folding best explains prion and amyloid diseases.

J. W. Kelly (1998)
PNAS 95, 930-932
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The WW Domain of Neural Protein FE65 Interacts with Proline-rich Motifs in Mena, the Mammalian Homolog of Drosophila Enabled.

K. S. Ermekova, N. Zambrano, H. Linn, G. Minopoli, F. Gertler, T. Russo, and M. Sudol (1997)
J. Biol. Chem. 272, 32869-32877
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Regulation of Amyloid Precursor Protein Catabolism Involves the Mitogen-Activated Protein Kinase Signal Transduction Pathway.

J. Mills, D. Laurent Charest, F. Lam, K. Beyreuther, N. Ida, S. L. Pelech, and P. B. Reiner (1997)
J. Neurosci. 17, 9415-9422
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Aggregated Amyloid-beta Protein Induces Cortical Neuronal Apoptosis and Concomitant "Apoptotic" Pattern of Gene Induction.

S. Estus, H. M. Tucker, C. van Rooyen, S. Wright, E. F. Brigham, M. Wogulis, and R. E. Rydel (1997)
J. Neurosci. 17, 7736-7745
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Prevention of Amyloid-Like Deposition by a Selective Prolyl Endopeptidase Inhibitor, Y-29794, in Senescence-Accelerated Mouse.

A. Kato, A. Fukunari, Y. Sakai, and T. Nakajima (1997)
J. Pharmacol. Exp. Ther. 283, 328-335
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Human Melanocytes as a Model System for Studies of Alzheimer Disease.

M. Yaar and B. A. Gilchrest (1997)
Arch Dermatol 133, 1287-1291
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Kinetic theory of fibrillogenesis of amyloid beta -protein.

A. Lomakin, D. B. Teplow, D. A. Kirschner, and G. B. Benedek (1997)
PNAS 94, 7942-7947
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Interaction between amyloid precursor protein and presenilins in mammalian cells: Implications for the pathogenesis of Alzheimer disease.

W. Xia, J. Zhang, R. Perez, E. H. Koo, and D. J. Selkoe (1997)
PNAS 94, 8208-8213
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Post-translational Processing of beta -Secretase (beta -Amyloid-converting Enzyme) and Its Ectodomain Shedding. THE PRO- AND TRANSMEMBRANE/CYTOSOLIC DOMAINS AFFECT ITS CELLULAR ACTIVITY AND AMYLOID-beta PRODUCTION.

S. Benjannet, A. Elagoz, L. Wickham, M. Mamarbachi, J. S. Munzer, A. Basak, C. Lazure, J. A. Cromlish, S. Sisodia, F. Checler, et al. (2001)
J. Biol. Chem. 276, 10879-10887
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beta -Amyloid Peptide-induced Apoptosis Regulated by a Novel Protein Containing a G Protein Activation Module.

E. M. Kajkowski, C. F. Lo, X. Ning, S. Walker, H. J. Sofia, W. Wang, W. Edris, P. Chanda, E. Wagner, S. Vile, et al. (2001)
J. Biol. Chem. 276, 18748-18756
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