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Science 10 January 1997:
Vol. 275. no. 5297, pp. 155 - 157
DOI: 10.1126/science.275.5297.155
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Research News

Elizabeth Pennisi

For decades, molecular biologists have suspected that a chemical modification called acetylation plays an important role in regulating gene activity, but they have had trouble proving it. Now researchers in several labs have identified several acetylating and deacetylating enzymes, and they have linked the reaction directly to the machinery that reads the genes: The acetylating enzymes have turned out to be proteins already known to associate with the transcription factors that turn genes on and off. What's more, the new work indicates that acetylation is important for cell growth control, and that when it becomes misdirected, cancer may develop.

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Regulation of Forestomach-specific Expression of the Murine Adenosine Deaminase Gene.
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Activation Domain-Specific and General Transcription Stimulation by Native Histone Acetyltransferase Complexes.
K. Ikeda, D. J. Steger, A. Eberharter, and J. L. Workman (1999)
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Histone deacetylase activity of Rpd3 is important for transcriptional repression in vivo.
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STATs and Gene Regulation.
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