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Science 11 October 1996:
Vol. 274. no. 5285, pp. 177 - 178
DOI: 10.1126/science.274.5285.177
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Research News

Jean Marx

Alzheimer's researchers have long wanted a realistic animal model of the disease, and last week's announcement in Science of a new, genetically engineered strain of mice that suffers both brain degeneration and memory deficits brought them a big step closer to that goal. The new mouse strain develops the same brain deposits of a protein called amyloid that are seen in human sufferers, and it should allow researchers to test the controversial idea that the amyloid deposition actually causes the brain changes that lead to memory loss. Already the mouse's developers have found that the animals have a biochemical abnormality that may be crucial to amyloid deposition--an increase in a particular "sticky" amyloid fragment.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Inflammation-Dependent Cerebral Deposition of Serum Amyloid A Protein in a Mouse Model of Amyloidosis.
J.-t. Guo, J. Yu, D. Grass, F. C. de Beer, and M. S. Kindy (2002)
J. Neurosci. 22, 5900-5909
   Abstract »    Full Text »    PDF »
Presenilin-1 P264L Knock-In Mutation: Differential Effects on Abeta Production, Amyloid Deposition, and Neuronal Vulnerability.
R. Siman, A. G. Reaume, M. J. Savage, S. Trusko, Y.-G. Lin, R. W. Scott, and D. G. Flood (2000)
J. Neurosci. 20, 8717-8726
   Abstract »    Full Text »    PDF »


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