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Science 27 September 1996:
Vol. 273. no. 5283, pp. 1795 - 1797
DOI: 10.1126/science.273.5283.1795
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Research News

Carol Potera

After focusing on free-floating bacteria for decades, microbiologists are now realizing that in nature, bacteria often aggregate in biofilms--clumps of microbes surrounded by slime and stuck to a surface. Biofilms foul pipes, contaminate medical implants, and sometimes even kill humans, for these tough microbial communities can resist antibiotics and the immune system.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Functional Tomographic Fluorescence Imaging of pH Microenvironments in Microbial Biofilms by Use of Silica Nanoparticle Sensors.
G. Hidalgo, A. Burns, E. Herz, A. G. Hay, P. L. Houston, U. Wiesner, and L. W. Lion (2009)
Appl. Envir. Microbiol. 75, 7426-7435
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Deletion of the rpoZ gene, encoding the {omega} subunit of RNA polymerase, results in pleiotropic surface-related phenotypes in Mycobacterium smegmatis.
R. Mathew, R. Mukherjee, R. Balachandar, and D. Chatterji (2006)
Microbiology 152, 1741-1750
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The role of therapeutic antimicrobial mouthrinses in clinical practice: Control of supragingival plaque and gingivitis.
M. L. BARNETT (2003)
J Am Dent Assoc 134, 699-704
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The Role of Biofilm Formation in Percutaneous Kirschner-Wire Fixation of Radial Fractures.
D. G. HARGREAVES, A. PAJKOS, A. K. DEVA, K. VICKERY, S. L. FILAN, and M. A. TONKIN (2002)
J Hand Surg Eur Vol. 27, 365-368
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Phosphate deprivation is associated with high resistance to latamoxef of gel-entrapped, sessile-like Escherichia coli cells.
S. Vilain, P. Cosette, G.-A. Junter, and T. Jouenne (2002)
J. Antimicrob. Chemother. 49, 315-320
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Probiotic agents to protect the urogenital tract against infection.
G. Reid (2001)
Am. J. Clinical Nutrition 73, 437S-443
   Abstract »    Full Text »    PDF »
Pulsed Ultrasound Enhances the Killing of Escherichia coli Biofilms by Aminoglycoside Antibiotics In Vivo.
A. M. Rediske, B. L. Roeder, J. L. Nelson, R. L. Robison, G. B. Schaalje, R. A. Robison, and W. G. Pitt (2000)
Antimicrob. Agents Chemother. 44, 771-772
   Abstract »    Full Text »    PDF »
Ultrasonic Enhancement of Antibiotic Action on Escherichia coli Biofilms: an In Vivo Model.
A. M. Rediske, B. L. Roeder, M. K. Brown, J. L. Nelson, R. L. Robison, D. O. Draper, G. B. Schaalje, R. A. Robison, and W. G. Pitt (1999)
Antimicrob. Agents Chemother. 43, 1211-1214
   Abstract »    Full Text »    PDF »
Vibrio cholerae O1 El Tor: Identification of a gene cluster required for the rugose colony type, exopolysaccharide production, chlorine resistance, and biofilm formation.
F. H. Yildiz and G. K. Schoolnik (1999)
PNAS 96, 4028-4033
   Abstract »    Full Text »    PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)