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Science 30 August 1996:
Vol. 273. no. 5279, pp. 1171 - 0
DOI: 10.1126/science.273.5279.1171
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Research News

Elizabeth Pennisi

The hormone estrogen is both a villain and a savior, thought to contribute to the development of breast and uterine cancers but also to protect women against heart attacks and osteoporosis. Now a study of an estrogenlike drug, reported on page 1222, may help explain the hormone's contradictory personality and open the way to designing drugs that block only its unwanted effects--or mimic only its beneficial ones. The drug, called raloxifene, sends its signals to the genes by different pathways depending on the tissue it is acting on. The natural hormone may owe its many guises to a similar variety of pathways.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Indole-3-carbinol stimulates transcription of the interferon gamma receptor 1 gene and augments interferon responsiveness in human breast cancer cells.
U. Chatterji, J. E. Riby, T. Taniguchi, E. L. Bjeldanes, L. F. Bjeldanes, and G. L. Firestone (2004)
Carcinogenesis 25, 1119-1128
   Abstract »    Full Text »    PDF »
Indole-3-Carbinol and 3-3'-Diindolylmethane Antiproliferative Signaling Pathways Control Cell-Cycle Gene Transcription in Human Breast Cancer Cells by Regulating Promoter-Sp1 Transcription Factor Interactions.
G. L. Firestone and L. F. Bjeldanes (2003)
J. Nutr. 133, 2448S-2455
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Indole-3-Carbinol and Tamoxifen Cooperate to Arrest the Cell Cycle of MCF-7 Human Breast Cancer Cells.
C. M. Cover, S. J. Hsieh, E. J. Cram, C. Hong, J. E. Riby, L. F. Bjeldanes, and G. L. Firestone (1999)
Cancer Res. 59, 1244-1251
   Abstract »    Full Text »    PDF »
Indole-3-carbinol Inhibits the Expression of Cyclin-dependent Kinase-6 and Induces a G1 Cell Cycle Arrest of Human Breast Cancer Cells Independent of Estrogen Receptor Signaling.
C. M. Cover, S. J. Hsieh, S. H. Tran, G. Hallden, G. S. Kim, L. F. Bjeldanes, and G. L. Firestone (1998)
J. Biol. Chem. 273, 3838-3847
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