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Science 9 August 1996:
Vol. 273. no. 5276, pp. 735 - 737
DOI: 10.1126/science.273.5276.735
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Research News

Marcia Barinaga

In the body, cell suicide, through a process called apoptosis or programmed cell death, is needed for normal embryonic development and proper immune system function, among other things. But until recently, very little was known about how the command to commit suicide is transmitted from the cell surface, where it's received, to the cell interior, where the apoptosis program is carried out. Now, in a recent burst of activity, a handful of labs have uncovered a complex maze of internal signaling pathways triggered by the death signal receptors. Researchers hope that unraveling these pathways will not only help them better understand the many processes in which apoptosis plays a role, but will also lead to new therapies for diseases, such as cancer and neurodegenerative disorders, in which apoptosis may go awry.

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THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Role of Sertoli Cells in Injury-Associated Testicular Germ Cell Apoptosis.
K. Boekelheide, S. L. Fleming, K. J. Johnson, S. R. Patel, and H. A. Schoenfeld (2000)
Experimental Biology and Medicine 225, 105-115
   Abstract »    Full Text »
Interleukin-1 Protects Transformed Keratinocytes from Tumor Necrosis Factor-related Apoptosis-inducing Ligand- and CD95-induced Apoptosis but Not from Ultraviolet Radiation-induced Apoptosis.
G. Kothny-Wilkes, D. Kulms, T. A. Luger, M. Kubin, and T. Schwarz (1999)
J. Biol. Chem. 274, 28916-28921
   Abstract »    Full Text »    PDF »
Minding the chaperones.
A. K. Alameddine (1999)
Ann. Thorac. Surg. 68, 628
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Thrombin Perturbs Neurite Outgrowth and Induces Apoptotic Cell Death in Enriched Chick Spinal Motoneuron Cultures through Caspase Activation.
V. L. Turgeon, E. D. Lloyd, S. Wang, B. W. Festoff, and L. J. Houenou (1998)
J. Neurosci. 18, 6882-6891
   Abstract »    Full Text »    PDF »
Nuclear Factor (NF)-{kappa}B-regulated X-chromosome-linked iap Gene Expression Protects Endothelial Cells from Tumor Necrosis Factor {alpha}-induced Apoptosis.
C. Stehlik, R. de Martin, I. Kumabashiri, J. A. Schmid, B. R. Binder, and J. Lipp (1998)
J. Exp. Med. 188, 211-216
   Abstract »    Full Text »    PDF »
Overexpression of a Novel Xenopus Rel mRNA Gene Induces Tumors in Early Embryos.
S. Yang, A. Lockwood, P. Hollett, R. Ford, and K. Kao (1998)
J. Biol. Chem. 273, 13746-13752
   Abstract »    Full Text »    PDF »
Review Article: A Review of Experimental Methylmercury Toxicity in Rats: Neuropathology and Evidence for Apoptosis.
K. Nagashima (1997)
Toxicol Pathol 25, 624-631
   Abstract »    PDF »
Apoptosis in the Heart.
W. S. Colucci (1996)
N. Engl. J. Med. 335, 1224-1226
   Full Text »


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