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Science 7 June 1996:
Vol. 272. no. 5267, pp. 1418 - 0
DOI: 10.1126/science.272.5267.1418
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News

Jocelyn Kaiser

A team of researchers from Tulane University, using a novel screening system based on genetically engineered yeast cells, reports on page 1489 of this issue that a mixture of two weakly estrogenic chemicals can be far more potent than the individual compounds. The findings are causing some scientists to take a fresh look at a controversy that has become a hot topic in the media and within Congress: Do estrogenlike pollutants pose a threat to human health? But the key question is still whether these hormonelike pollutants, much weaker than natural estrogens in the body, have enough clout to harm humans.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
From estrogen to androgen receptor: A new pathway for sex hormones in prostate.
S. Yeh, H. Miyamoto, H. Shima, and C. Chang (1998)
PNAS 95, 5527-5532
   Abstract »    Full Text »    PDF »
Estrogenic Activity of a Dieldrin/Toxaphene Mixture in the Mouse Uterus, MCF-7 Human Breast Cancer Cells, and Yeast-Based Estrogen Receptor Assays: No Apparent Synergism.
K. Ramamoorthy, F. Wang, I-C. Chen, J. D. Norris, D. P. McDonnell, L. S. Leonard, K. W. Gaido, W. P. Bocchinfuso, K. S. Korach, and S. Safe (1997)
Endocrinology 138, 1520-1527
   Abstract »    Full Text »    PDF »
EVIDENCE OF DANGER FROM ENVIRONMENTAL ESTROGENIC CHEMICALS.
(1996)
Journal Watch (General) 1996, 2
   Full Text »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)