Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Science 24 May 1996:
Vol. 272. no. 5265, pp. 1124 - 1125
DOI: 10.1126/science.272.5265.1124
Prev | Table of Contents | Next

Perspectives

David D. Ho

A single measurement of the amount of the human immunodeficiency virus (HIV) in a patient's blood can predict the subsequent risk of acquired immunodeficiency syndrome (AIDS) or death, even before the patient shows signs of the disease--so reports a paper (Mellors et al., p.1167) in this issue. In his Perspective, Ho discusses why this is the case and why measurement of viral loads will become extremely useful clinically.

The author is at the Aaron Diamond AIDS Research Center, Rockefeller University, 455 First Avenue, New York, NY 10016, USA.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
The dual role of dendritic cells in the immune response to human immunodeficiency virus type 1 infection.
I. B. Hogue, S. H. Bajaria, B. A. Fallert, S. Qin, T. A. Reinhart, and D. E. Kirschner (2008)
J. Gen. Virol. 89, 2228-2239
   Abstract »    Full Text »    PDF »
Use of viral loads in blood and nasopharyngeal secretions for the diagnosis of EHV-1 infection in field cases.
N. Pusterla, S. Mapes, and W. D. Wilson (2008)
Vet Rec. 162, 728-729
   Full Text »    PDF »
Quantitative Analysis of Human Immunodeficiency Virus Type 1-Infected CD4+ Cell Proteome: Dysregulated Cell Cycle Progression and Nuclear Transport Coincide with Robust Virus Production.
E. Y. Chan, W.-J. Qian, D. L. Diamond, T. Liu, M. A. Gritsenko, M. E. Monroe, D. G. Camp II, R. D. Smith, and M. G. Katze (2007)
J. Virol. 81, 7571-7583
   Abstract »    Full Text »    PDF »
Inhibition of HIV-1 replication in macrophages by a heterodinucleotide of lamivudine and tenofovir.
L. Rossi, P. Franchetti, F. Pierige, L. Cappellacci, S. Serafini, E. Balestra, C.-F. Perno, M. Grifantini, R. Calio, and M. Magnani (2007)
J. Antimicrob. Chemother. 59, 666-675
   Abstract »    Full Text »    PDF »
The Rate of Serious Bacterial Infections Among HIV-Infected Children With Immune Reconstitution Who Have Discontinued Opportunistic Infection Prophylaxis.
S. Nachman, P. Gona, W. Dankner, A. Weinberg, R. Yogev, A. Gershon, M. Rathore, J. S. Read, S. Huang, C. Elgie, et al. (2005)
Pediatrics 115, e488-e494
   Abstract »    Full Text »    PDF »
Displacement of SATB1-Bound Histone Deacetylase 1 Corepressor by the Human Immunodeficiency Virus Type 1 Transactivator Induces Expression of Interleukin-2 and Its Receptor in T Cells.
P. P. Kumar, P. K. Purbey, D. S. Ravi, D. Mitra, and S. Galande (2005)
Mol. Cell. Biol. 25, 1620-1633
   Abstract »    Full Text »    PDF »
Human Immunodeficiency Virus: Anesthetic and Obstetric Considerations.
S. Evron, M. Glezerman, E. Harow, O. Sadan, and T. Ezri (2004)
Anesth. Analg. 98, 503-511
   Abstract »    Full Text »    PDF »
Long-Term HIV/AIDS Survival Estimation in the Highly Active Antiretroviral Therapy Era.
J. T. King Jr., A. C. Justice, M. S. Roberts, C.-C. H. Chang, and J. S. Fusco (2003)
Med Decis Making 23, 9-20
   Abstract »    PDF »
Intrapatient Diversity and Its Correlation with Viral Setpoint in Human Immunodeficiency Virus Type 1 CRF02_A/G-IbNG Infection.
I. Mani, P. Gilbert, J.-L. Sankale, G. Eisen, S. Mboup, and P. J. Kanki (2002)
J. Virol. 76, 10745-10755
   Abstract »    Full Text »    PDF »
Gender-related differences in susceptibility, early virus dissemination and immunosuppression in mice infected with Friend murine leukaemia virus variant FIS-2.
T. Bruland, H. Y. Dai, L. A. S. Lavik, L. I. Kristiansen, and A. Dalen (2001)
J. Gen. Virol. 82, 1821-1827
   Abstract »    Full Text »    PDF »
Therapeutic Effect of a Gag-Nuclease Fusion Protein against Retroviral Infection In Vivo.
G. Schumann, M. Hermankova, K. Cannon, J. L. Mankowski, and J. D. Boeke (2001)
J. Virol. 75, 7030-7041
   Abstract »    Full Text »
Inhibition of needlestick-induced simulated viremia by local measures.
F. Robicsek, A. A. Fokin, T. N. Masters, and J. W. Cook (2000)
Ann. Thorac. Surg. 70, 229-233
   Abstract »    Full Text »    PDF »
Promoting Early Detection of Human Immunodeficiency Virus Infection Among Adolescents.
M. J. Rotheram-Borus and D. Futterman (2000)
Arch Pediatr Adolesc Med 154, 435-439
   Abstract »    Full Text »    PDF »
Effects of recombinant ovine interferon-{tau} on ovine lentivirus replication and progression of disease.
R. A. Juste, T. L. Ott, J. Kwang, F. W. Bazer, and A. de la Concha-Bermejillo (2000)
J. Gen. Virol. 81, 525-532
   Abstract »    Full Text »
A simple relationship between viral load and survival time in HIV-1 infection.
R. A. Arnaout, A. L. Lloyd, T. R. O'Brien, J. J. Goedert, J. M. Leonard, and M. A. Nowak (1999)
PNAS 96, 11549-11553
   Abstract »    Full Text »    PDF »
Users' Guides to the Medical Literature: XIX. Applying Clinical Trial Results; A. How to Use an Article Measuring the Effect of an Intervention on Surrogate End Points.
H. C. Bucher, G. H. Guyatt, D. J. Cook, A. Holbrook, F. A. McAlister, and for the Evidence-Based Medicine Working Group (1999)
JAMA 282, 771-778
   Full Text »    PDF »
Identification of inflections in T-cell counts among HIV-1-infected individuals and relationship with progression to clinical AIDS.
S. J. Gange, A. Munoz, J. S. Chmiel, A. D. Donnenberg, L. M. Kirstein, R. Detels, and J. B. Margolick (1998)
PNAS 95, 10848-10853
   Abstract »    Full Text »    PDF »
Effect of UV-B Phototherapy on Plasma HIV Type 1 RNA Viral Level: A Self-controlled Prospective Study.
J. M. Gelfand, D. Rudikoff, M. Lebwohl, and M. E. Klotman (1998)
Arch Dermatol 134, 940-945
   Abstract »    Full Text »    PDF »
Influence of host genes on HIV-1 disease progression.
M. Roger (1998)
FASEB J 12, 625-632
   Abstract »    Full Text »
Productive Infection of Neonatal CD8+ T Lymphocytes by HIV-1.
L. P. Yang, J. L. Riley, R. G. Carroll, C. H. June, J. Hoxie, B. K. Patterson, Y. Ohshima, R. J. Hodes, and G. Delespesse (1998)
J. Exp. Med. 187, 1139-1144
   Abstract »    Full Text »    PDF »
Declining Morbidity and Mortality among Patients with Advanced Human Immunodeficiency Virus Infection.
F. J. Palella, K. M. Delaney, A. C. Moorman, M. O. Loveless, J. Fuhrer, G. A. Satten, D. J. Aschman, S. D. Holmberg, and The HIV Outpatient Study Investigators (1998)
N. Engl. J. Med. 338, 853-860
   Abstract »    Full Text »    PDF »
Stability of Human Immunodeficiency Virus RNA in Blood Specimens as Measured by a Commercial PCR-Based Assay.
K. Sebire, K. McGavin, S. Land, T. Middleton, and C. Birch (1998)
J. Clin. Microbiol. 36, 493-498
   Abstract »    Full Text »
Transgenic Mice Expressing Human Immunodeficiency Virus Type 1 in Immune Cells Develop a Severe AIDS-Like Disease.
Z. Hanna, D. G. Kay, M. Cool, S. Jothy, N. Rebai, and P. Jolicoeur (1998)
J. Virol. 72, 121-132
   Abstract »    Full Text »    PDF »
Viral Load and Disease Progression in Infants Infected with Human Immunodeficiency Virus Type 1.
W. T. Shearer, T. C. Quinn, P. LaRussa, J. F. Lew, L. Mofenson, S. Almy, K. Rich, E. Handelsman, C. Diaz, M. Pagano, et al. (1997)
N. Engl. J. Med. 336, 1337-1342
   Abstract »    Full Text »    PDF »
Intravenous Anti-D Treatment of Immune Thrombocytopenic Purpura: Experience in 272 Patients.
A. Scaradavou, B. Woo, B.M.R. Woloski, S. Cunningham-Rundles, L. J. Ettinger, L. M. Aledort, and J. B. Bussel (1997)
Blood 89, 2689-2700
   Abstract »    Full Text »    PDF »


ADVERTISEMENT
Click Me!

ADVERTISEMENT
Click Me!

To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)